Neoplastic Transformation is a multistep cellular pathological process in which normal cells acquire heritable genetic and epigenetic alterations that confer autonomous, dysregulated growth and other neoplastic phenotypes, thereby converting them into tumorigenic cells.
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Signatures of mutational processes in human cancer
Ludmil B. Alexandrov, Serena Nik‐Zainal, David C. Wedge et al. · Nature · 2013 · 10.1K citations · Full text
Medicine, Cancer Biology, Oncology +14
Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer
Manabu Soda, Young Lim Choi, Munehiro Enomoto et al. · Nature · 2007 · 5.4K citations
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Lawrence A. Donehower, Michele Harvey, Betty L. Slagle et al. · Nature · 1992 · 4.7K citations
Paul Polakis · Genes & Development · 2000 · 3.2K citations · Full text
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Institute for Experimental Endocrinology and Oncology, Italy
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Whitehead Institute for Biomedical Research, United States
22 publications · 14.4K citations
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Harvard University
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National Cancer Institute
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Dana-Farber Cancer Institute
Boston, United States
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496 publications
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Bethesda, United States
60 h-index
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Memorial Sloan Kettering Cancer Center
New York, United States
58 h-index
583 publications
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University of California, San Francisco
San Francisco, United States
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280 publications
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The University of Texas MD Anderson Cancer Center
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