Concepedia

Replicative Immortality

Replicative Immortality is a hallmark of neoplastic transformation characterized by the acquisition of unlimited proliferative potential in cancer cells, distinguishing them from normal somatic cells that undergo replicative senescence due to telomere shortening.

569

Publications

56.5K

Citations

3K

Authors

860

Institutions

Publications per year

2017–2026

80

Parents

Publications

569

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

Nam W. Kim, Mieczyslaw A. Piatyszek, Karen R. Prowse et al. · Science · 1994 · 7.1K citations

, , +16

Telomere elongation in immortal human cells without detectable telomerase activity.

Tracy M. Bryan, Anna Englezou, Jeena Gupta et al. · The EMBO Journal · 1995 · 1.3K citations · Full text

, , +13

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells

Tohru Kiyono, Scott A. Foster, Jenn I. Koop et al. · Nature · 1998 · 1.2K citations

, , +14

Human Keratinocytes That Express hTERT and Also Bypass a p16<sup>INK4a</sup>-Enforced Mechanism That Limits Life Span Become Immortal yet Retain Normal Growth and Differentiation Characteristics

Mark A. Dickson, William C. Hahn, Yasushi Ino et al. · Molecular and Cellular Biology · 2000 · 1.1K citations · Full text

, , +12

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

Simona Parrinello, Enrique Samper, Ana Krtolica et al. · Nature Cell Biology · 2003 · 1.1K citations · Full text

, , +13

1–5 of 569

Authors

3K

  1. JW
    Jerry W. Shay

    The University of Texas Southwestern Medical Center, United States

    19 publications · 11.1K citations

    18

    h-index

  2. WE
    Woodring E. Wright

    The University of Texas Southwestern Medical Center, United States

    13 publications · 10.2K citations

    13

    h-index

  3. RR
    Roger R. Reddel

    Children's Medical Research Institute, Australia

    11 publications · 2.1K citations

    11

    h-index

  4. PJ
    Parmjit Jat

    University College London, United Kingdom

    8 publications · 550 citations

    8

    h-index

  5. WC
    William C. Hahn

    Dana-Farber Cancer Institute, United States

    7 publications · 2.5K citations

    7

    h-index

1–5 of 3K

Institutions

860

  1. Harvard University

    Cambridge, United States

    19 h-index

    65 publications

    14.9K citations

  2. The University of Texas Southwestern Medical Center

    Dallas, United States

    18 h-index

    72 publications

    38.6K citations

  3. Children's Medical Research Institute

    Sydney, Australia

    12 h-index

    46 publications

    9.9K citations

  4. National Cancer Institute

    Bethesda, United States

    11 h-index

    30 publications

    3.8K citations

  5. University College London

    London, United Kingdom

    10 h-index

    42 publications

    4.3K citations

  6. Brigham and Women's Hospital

    Boston, United States

    10 h-index

    29 publications

    8.5K citations

  7. Lawrence Berkeley National Laboratory

    Berkeley, United States

    10 h-index

    29 publications

    6K citations

  8. Baylor College of Medicine

    Houston, United States

    10 h-index

    27 publications

    2.6K citations

1–8 of 860

Venues

  1. PubMed

    Repository · 45 publications · 3.3K citations

    29

    h-index

  2. Oncogene

    22 publications · 1.5K citations

    21

    h-index

  3. Experimental Cell Research

    ECR · 22 publications · 1.4K citations

    19

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 19 publications · 3.3K citations

    17

    h-index

  5. Molecular and Cellular Biology

    MCB · 14 publications · 2.9K citations

    14

    h-index

1–5