Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

Peter Vaupel, F. Kallinowski, Paul Okunieff · PubMed · 1989 · 3.4K citations

Medicine, Cancer Biology, Oncology +16

QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES

George J. Todaro, Howard Green · The Journal of Cell Biology · 1963 · 2.8K citations · Full text

Life Sciences, Biology, Cell Biology +12

Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

Marı́a A. Blasco, Han‐Woong Lee, M. Prakash Hande et al. · Cell · 1997 · 2.1K citations · Full text

Life Sciences, Genetics, Oncology +17

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

Takehiko Kamijo, Frédérique Zindy, Martine F. Roussel et al. · Cell · 1997 · 1.6K citations · Full text

Medicine, Genetics, Molecular Genetics +16

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

Norman E. Sharpless, Nabeel Bardeesy, Kee-Ho Lee et al. · Nature · 2001 · 850 citations

Medicine, Molecular Genetics, Oncology +12