Concepedia

Replicative Senescence

Replicative Senescence is a cellular state of irreversible growth arrest that cells enter after a finite number of divisions, distinguished from other forms of cell cycle arrest by its causation through progressive telomere shortening and its role as a tumor-suppressive mechanism in the context of cell expansion and telomere biology in cancer.

1.5K

Publications

149.6K

Citations

7.5K

Authors

1.7K

Institutions

Publications per year

2017–2026

341

Parents

Publications

1.5K

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Goberdhan P. Dimri, X Lee, George Basile et al. · Proceedings of the National Academy of Sciences · 1995 · 7.4K citations · Full text

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Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

Andrea Bodnár, Michel Ouellette, Maria Frolkis et al. · Science · 1998 · 5K citations

, , +17

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Zhenbang Chen, Lloyd C. Trotman, David R. Shaffer et al. · Nature · 2005 · 2K citations · Full text

, , +16

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

Raffaella Di Micco, Marzia Fumagalli, Angelo Cicalese et al. · Nature · 2006 · 1.8K citations

, , +16

Telomere reduction in human colorectal carcinoma and with ageing

N D Hastie, Maureen Dempster, Malcolm G. Dunlop et al. · Nature · 1990 · 1.7K citations

, , +14

1–5 of 1.5K

Authors

7.5K

  1. WW
    Wolfgang Wagner

    RWTH Aachen University, Germany

    18 publications · 3.2K citations

    18

    h-index

  2. JW
    Jerry W. Shay

    The University of Texas Southwestern Medical Center, United States

    21 publications · 7.9K citations

    18

    h-index

  3. RB
    Rita B. Effros

    University of California, Los Angeles, United States

    16 publications · 2K citations

    16

    h-index

  4. JC
    Judith Campisi

    Buck Institute for Research on Aging, United States

    15 publications · 4.4K citations

    15

    h-index

  5. DK
    David Kipling

    Cardiff University, United Kingdom

    16 publications · 806 citations

    15

    h-index

1–5 of 7.5K

Institutions

1.7K

  1. Centre National de la Recherche Scientifique

    Paris, France

    29 h-index

    175 publications

    15.3K citations

  2. National Institutes of Health

    Bethesda, United States

    28 h-index

    144 publications

    30.5K citations

  3. Harvard University

    Cambridge, United States

    27 h-index

    96 publications

    15.1K citations

  4. Inserm

    Paris, France

    24 h-index

    172 publications

    22.7K citations

  5. University College London

    London, United Kingdom

    23 h-index

    109 publications

    13.6K citations

  6. University of California, Los Angeles

    Los Angeles, United States

    23 h-index

    78 publications

    5.2K citations

  7. University of Washington

    Seattle, United States

    22 h-index

    180 publications

    24.9K citations

  8. Peking University

    Beijing, China

    22 h-index

    157 publications

    7.9K citations

1–8 of 1.7K

Venues

  1. Aging Cell

    53 publications · 5.9K citations

    40

    h-index

  2. Journal of Biological Chemistry

    JBC · 48 publications · 6.3K citations

    39

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 41 publications · 14.3K citations

    35

    h-index

  4. PubMed

    Repository · 63 publications · 5.6K citations

    35

    h-index

  5. PLoS ONE

    49 publications · 4.2K citations

    33

    h-index

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