Concepedia

Differentiation Blockade

Differentiation Blockade is a pathological mechanism in neoplastic transformation whereby precursor cells are arrested in an undifferentiated state due to dysregulated signaling pathways, preventing their progression through normal cellular differentiation.

59

Publications

4.5K

Citations

426

Authors

185

Institutions

Publications per year

2017–2026

16

Variants

Differentiation Arrest

Parents

Publications

59

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

Martin Göttlicher · The EMBO Journal · 2001 · 1.9K citations · Full text

, , +10

The Promyelocytic Leukemia Zinc Finger–MicroRNA-221/-222 Pathway Controls Melanoma Progression through Multiple Oncogenic Mechanisms

Federica Felicetti, Maria Cristina Errico, Lisabianca Bottero et al. · Cancer Research · 2008 · 373 citations · Full text

, , +17

Phosphatidylinositol 3-Kinase Inhibitors Block Differentiation of Skeletal Muscle Cells

Perla Kaliman, Francesc Viñals, Xavier Testar et al. · Journal of Biological Chemistry · 1996 · 209 citations · Full text

, , +17

Cell differentiation and bypassing of genetic defects in the suppression of malignancy.

Leo Sachs · PubMed · 1987 · 118 citations

, , +14

Insm1 (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympatho-adrenal lineage

Hendrik Wildner, Mathias S. Gierl, Michael Strehle et al. · Development · 2007 · 112 citations

, , +15

1–5 of 59

Authors

426

  1. AU
    Andrea Urbani

    Fondazione Santa Lucia, Italy

    2 publications · 64 citations

    2

    h-index

  2. SD
    Simona D’Aguanno

    Istituti di Ricovero e Cura a Carattere Scientifico, Italy

    2 publications · 64 citations

    2

    h-index

  3. ED
    Ethan Dmitrovsky

    Memorial Sloan Kettering Cancer Center, United States

    2 publications · 33 citations

    2

    h-index

  4. GN
    Giordano Nicoletti

    University of Bologna, Italy

    1 publications · 47 citations

    1

    h-index

  5. HD
    Haojie Dong

    Zhejiang University, China

    1 publications · 29 citations

    1

    h-index

1–5 of 426

Institutions

185

  1. Istituti di Ricovero e Cura a Carattere Scientifico

    Rome, Italy

    3 h-index

    4 publications

    528 citations

  2. Dana-Farber Cancer Institute

    Boston, United States

    2 h-index

    2 publications

    42 citations

  3. Fondazione Santa Lucia

    Rome, Italy

    2 h-index

    10 publications

    524 citations

  4. Massachusetts General Hospital

    Boston, United States

    2 h-index

    3 publications

    217 citations

  5. The University of Texas at San Antonio Health Science Center

    San Antonio, United States

    2 h-index

    9 publications

    383 citations

  6. McGill University

    Montreal, Canada

    2 h-index

    4 publications

    138 citations

  7. Thoracic Surgery Foundation

    Chicago, United States

    2 h-index

    2 publications

    33 citations

  8. Pediatrics and Genetics

    Alpharetta, United States

    2 h-index

    2 publications

    89 citations

1–8 of 185

Venues

  1. PubMed

    Repository · 5 publications · 233 citations

    5

    h-index

  2. Blood

    4 publications · 103 citations

    4

    h-index

  3. Journal of Biological Chemistry

    JBC · 4 publications · 429 citations

    4

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 120 citations

    3

    h-index

  5. Cancer Research

    3 publications · 462 citations

    3

    h-index

1–5