Concepedia

Synthetic Lethal Screening

Synthetic Lethal Screening is a systematic experimental methodology in functional genomics that identifies pairs of genes whose simultaneous disruption leads to cell death, while disruption of either gene alone is non-lethal, thereby revealing context-specific genetic dependencies relevant to precision cancer therapeutics.

438

Publications

33K

Citations

3.7K

Authors

791

Institutions

Publications per year

2017–2026

179

Parents

Publications

438

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

Wan Seok Yang, Brent R. Stockwell · Chemistry & Biology · 2008 · 1.9K citations · Full text

, , +14

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

Sonam Dolma, Stephen L. Lessnick, William C. Hahn et al. · Cancer Cell · 2003 · 1.4K citations · Full text

, , +13

Gene essentiality and synthetic lethality in haploid human cells

Vincent A. Blomen, Peter Májek, Lucas T. Jae et al. · Science · 2015 · 948 citations

, , +17

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening

E. Robert McDonald, Antoine de Weck, Michael R. Schlabach et al. · Cell · 2017 · 701 citations · Full text

, , +17

<i>tp53</i> mutant zebrafish develop malignant peripheral nerve sheath tumors

Stéphane Berghmans, Ryan D. Murphey, Erno Wienholds et al. · Proceedings of the National Academy of Sciences · 2005 · 617 citations · Full text

, , +17

1–5 of 438

Authors

3.7K

  1. CJ
    Christopher J. Lord

    Institute of Cancer Research, United Kingdom

    14 publications · 1.4K citations

    14

    h-index

  2. AA
    Alan Ashworth

    Institute of Cancer Research, United Kingdom

    11 publications · 1.2K citations

    11

    h-index

  3. RB
    Rachel Brough

    Breast Cancer Now, United Kingdom

    8 publications · 1.2K citations

    8

    h-index

  4. WC
    William C. Hahn

    Dana-Farber Cancer Institute, United States

    8 publications · 1.7K citations

    8

    h-index

  5. CB
    Charles Boone

    University of Toronto, Canada

    6 publications · 965 citations

    6

    h-index

1–5 of 3.7K

Institutions

791

  1. Harvard University

    Cambridge, United States

    22 h-index

    138 publications

    20.5K citations

  2. Broad Institute

    Cambridge, United States

    17 h-index

    189 publications

    13.9K citations

  3. Institute of Cancer Research

    London, United Kingdom

    15 h-index

    131 publications

    16.2K citations

  4. Dana-Farber Cancer Institute

    Boston, United States

    15 h-index

    112 publications

    17.3K citations

  5. Howard Hughes Medical Institute

    Chevy Chase, United States

    14 h-index

    41 publications

    6.8K citations

  6. University of Toronto

    Toronto, Canada

    14 h-index

    93 publications

    14.9K citations

  7. The University of Texas MD Anderson Cancer Center

    Houston, United States

    14 h-index

    94 publications

    8.4K citations

  8. Breast Cancer Now

    London, United Kingdom

    12 h-index

    115 publications

    11.1K citations

1–8 of 791

Venues

  1. Cancer Research

    23 publications · 1.9K citations

    21

    h-index

  2. Genetics

    28 publications · 1.6K citations

    21

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 18 publications · 2.7K citations

    17

    h-index

  4. Molecular and Cellular Biology

    MCB · 18 publications · 1.7K citations

    17

    h-index

  5. Oncotarget

    15 publications · 598 citations

    14

    h-index

1–5