Concepedia

Conditional Synthetic Lethality

Conditional Synthetic Lethality is a genetic interaction in which the simultaneous perturbation of two or more genes results in cell death only under specific environmental or genetic conditions, distinguishing it from constitutive synthetic lethality by its context-dependent manifestation.

44

Publications

2.4K

Citations

186

Authors

77

Institutions

Publications per year

2017–2026

9

Parents

Publications

44

Conditional Lethality of <i>recA</i> and <i>recB</i> Derivatives of a Strain of <i>Escherichia coli</i> K-12 with a Temperature-Sensitive Deoxyribonucleic Acid Polymerase I

Marilyn Monk, James Kinross · Journal of Bacteriology · 1972 · 270 citations · Full text

, , +12

Conditional Lethality, Division Defects, Membrane Involution, and Endocytosis in<i>mre</i>and<i>mrd</i>Shape Mutants of<i>Escherichia coli</i>

Felipe O. Bendezú, Piet A. J. de Boer · Journal of Bacteriology · 2007 · 208 citations · Full text

, , +16

Multiple Genetic Pathways for Restarting DNA Replication Forks in <i>Escherichia coli</i> K-12

Steven J. Sandler · Genetics · 2000 · 172 citations · Full text

, , +14

Genome‐scale gene/reaction essentiality and synthetic lethality analysis

Patrick F. Suthers, Alireza Zomorrodi, Costas D. Maranas · Molecular Systems Biology · 2009 · 172 citations · Full text

, , +14

Inhibiting Wee1 and ATR kinases produces tumor-selective synthetic lethality and suppresses metastasis

Amirali B. Bukhari, Cody W. Lewis, Joanna J. Pearce et al. · Journal of Clinical Investigation · 2019 · 133 citations · Full text

, , +17

1–5 of 44

Authors

186

  1. SS
    Stewart Shuman

    Kettering University, United States

    2 publications · 24 citations

    2

    h-index

  2. AJ
    Allen J. Roth

    Cornell University, United States

    2 publications · 24 citations

    2

    h-index

  3. CC
    Christine Costigan

    Yale University, United States

    2 publications · 165 citations

    2

    h-index

  4. MS
    M Snyder

    Stanford University, United States

    2 publications · 165 citations

    2

    h-index

  5. DK
    David Kolodrubetz

    The University of Texas at San Antonio Health Science Center, United States

    2 publications · 165 citations

    2

    h-index

1–5 of 186

Institutions

77

  1. Yale University

    New Haven, United States

    3 h-index

    7 publications

    547 citations

  2. Harvard University

    Cambridge, United States

    3 h-index

    6 publications

    230 citations

  3. National Cancer Institute

    Bethesda, United States

    3 h-index

    11 publications

    241 citations

  4. University of Alberta

    Edmonton, Canada

    2 h-index

    8 publications

    820 citations

  5. Stanford University

    Stanford, United States

    2 h-index

    5 publications

    198 citations

  6. California Institute of Technology

    Pasadena, United States

    2 h-index

    7 publications

    423 citations

  7. Stony Brook University

    Stony Brook, United States

    2 h-index

    3 publications

    89 citations

  8. University of Toronto

    Toronto, Canada

    2 h-index

    7 publications

    391 citations

1–8 of 77

Venues

  1. Genetics

    6 publications · 294 citations

    6

    h-index

  2. Molecular and Cellular Biology

    MCB · 4 publications · 217 citations

    4

    h-index

  3. Molecular Microbiology

    3 publications · 78 citations

    3

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 122 citations

    3

    h-index

  5. Journal of Bacteriology

    JB · 3 publications · 493 citations

    3

    h-index

1–5