Concepedia

High-throughput Screening

High-Throughput Screening is a laboratory methodology that systematically and rapidly evaluates large libraries of chemical, biological, or genetic entities against a specific molecular target or phenotypic outcome to identify active compounds or functional elements with relevance to chemical genomics, directed evolution, and drug discovery.

4K

Publications

253.8K

Citations

19.9K

Authors

3.4K

Institutions

Publications per year

2017–2026

1.3K

Variants

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Publications

4K

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Ji-Hu Zhang, Thomas D.Y. Chung, Kevin R. Oldenburg · SLAS DISCOVERY · 1999 · 7K citations · Full text

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The <tt>sva</tt> package for removing batch effects and other unwanted variation in high-throughput experiments

Jeffrey T. Leek, W. Evan Johnson, Hilary S. Parker et al. · Bioinformatics · 2012 · 6.7K citations · Full text

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New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

Jonathan B. Baell, Georgina A. Holloway · Journal of Medicinal Chemistry · 2010 · 3.9K citations

, , +14

Printing Proteins as Microarrays for High-Throughput Function Determination

Gavin MacBeath, Stuart L. Schreiber · Science · 2000 · 2.8K citations

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Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

Piyush B. Gupta, Tamer T. Önder, Guozhi Jiang et al. · Cell · 2009 · 2.4K citations · Full text

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1–5 of 4K

Authors

19.9K

  1. RH
    Ruili Huang

    National Institutes of Health, United States

    38 publications · 3K citations

    28

    h-index

  2. CP
    Christopher P. Austin

    National Institutes of Health, United States

    30 publications · 3.2K citations

    25

    h-index

  3. RJ
    Richard Judson

    Environmental Protection Agency, United States

    28 publications · 4K citations

    25

    h-index

  4. MX
    Menghang Xia

    National Institutes of Health, United States

    31 publications · 2.6K citations

    24

    h-index

  5. AS
    Anton Simeonov

    National Institutes of Health, United States

    32 publications · 2.9K citations

    23

    h-index

1–5 of 19.9K

Institutions

3.4K

  1. National Institutes of Health

    Bethesda, United States

    53 h-index

    648 publications

    64.4K citations

  2. Harvard University

    Cambridge, United States

    53 h-index

    386 publications

    52.7K citations

  3. Research Triangle Park Foundation

    Durham, United States

    47 h-index

    305 publications

    51.1K citations

  4. Environmental Protection Agency

    Washington, United States

    44 h-index

    334 publications

    51.5K citations

  5. Broad Institute

    Cambridge, United States

    36 h-index

    278 publications

    39.2K citations

  6. Massachusetts Institute of Technology

    Cambridge, United States

    36 h-index

    180 publications

    31.6K citations

  7. Scripps Research Institute

    San Diego, United States

    35 h-index

    191 publications

    14.3K citations

  8. Novartis (Switzerland)

    Basel, Switzerland

    35 h-index

    269 publications

    61.5K citations

1–8 of 3.4K

Venues

  1. SLAS DISCOVERY

    295 publications · 19.5K citations

    58

    h-index

  2. Journal of Chemical Information and Modeling

    JCIM · 160 publications · 10.6K citations

    57

    h-index

  3. Analytical Biochemistry

    92 publications · 3.8K citations

    36

    h-index

  4. Journal of Medicinal Chemistry

    60 publications · 13K citations

    36

    h-index

  5. PLoS ONE

    76 publications · 3.5K citations

    35

    h-index

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