Mark Sylvester

Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency

Philip D. Edwards, Jeffrey S. Albert, Mark Sylvester et al. · Journal of Medicinal Chemistry · 2007 · 210 citations · Full text

Linear Non-competitive Inhibition of Solubilized Human γ-Secretase by Pepstatin A Methylester, L685458, Sulfonamides, and Benzodiazepines

Gaochao Tian, Cynthia D. Sobotka‐Briner, John R. Zysk et al. · Journal of Biological Chemistry · 2002 · 145 citations · Full text

Cerebral Deposition, Neurochemical Biomarkers, Peptide Science +22

Rational design of a new antibiotic class for drug-resistant infections

Thomas F. Durand-Réville, Alita A. Miller, John P. O’Donnell et al. · Nature · 2021 · 134 citations

Antimicrobial Susceptibility, Antibiotics, Rational Design +8

Toward the Rational Design of Carbapenem Uptake in Pseudomonas aeruginosa

Vincent M. Isabella, Arthur J. Campbell, John I. Manchester et al. · Chemistry & Biology · 2015 · 63 citations

Antimicrobial Susceptibility, Health Sciences, Antibiotics +9

Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering

Jeffrey W. Johannes, Lynsie Almeida, Kevin Daly et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 62 citations · Full text

Medicine, Natural Sciences, Molecular Biology +5