Lynsie Almeida

Discovery of 5-Chloro-<i>N</i>²-[(1<i>S</i>)-1-(5-fluoropyrimidin-2-yl)ethyl]-<i>N</i>⁴-(5-methyl-1<i>H</i>-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a Novel Inhibitor of the Jak/Stat Pathway

Stephanos Ioannidis, Michelle L. Lamb, Tao Wang et al. · Journal of Medicinal Chemistry · 2010 · 123 citations · Full text

Novel Inhibitor, Potent Jak2 Inhibitor, Chemical Biology +24

Discovery of Checkpoint Kinase Inhibitor (<i>S</i>)-5-(3-Fluorophenyl)-<i>N</i>-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by Structure-Based Design and Optimization of Thiophenecarboxamide Ureas

Vibha Oza, Susan Ashwell, Lynsie Almeida et al. · Journal of Medicinal Chemistry · 2012 · 67 citations · Full text

Drug Target, Molecular Biology, Chemical Biology +20

Pyrimidinone Nicotinamide Mimetics as Selective Tankyrase and Wnt Pathway Inhibitors Suitable for in Vivo Pharmacology

Jeffrey W. Johannes, Lynsie Almeida, Bernard Barlaam et al. · ACS Medicinal Chemistry Letters · 2015 · 64 citations · Full text

Pharmacotherapy, Cancer Biology, Tumor Biology +18

Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering

Jeffrey W. Johannes, Lynsie Almeida, Kevin Daly et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 62 citations · Full text

Medicine, Natural Sciences, Molecular Biology +5

Discovery of 1-Methyl-1<i>H</i>-imidazole Derivatives as Potent Jak2 Inhibitors

Qibin Su, Stephanos Ioannidis, Claudio Chuaqui et al. · Journal of Medicinal Chemistry · 2013 · 55 citations · Full text

Compound 19A, Pharmaceutical Chemistry, Tumor Biology +18