Lynsie Almeida

Discovery of 5-Chloro-<i>N</i>²-[(1<i>S</i>)-1-(5-fluoropyrimidin-2-yl)ethyl]-<i>N</i>⁴-(5-methyl-1<i>H</i>-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a Novel Inhibitor of the Jak/Stat Pathway

Stephanos Ioannidis, Michelle L. Lamb, Tao Wang et al. · Journal of Medicinal Chemistry · 2010 · 123 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Discovery of Checkpoint Kinase Inhibitor (<i>S</i>)-5-(3-Fluorophenyl)-<i>N</i>-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by Structure-Based Design and Optimization of Thiophenecarboxamide Ureas

Vibha Oza, Susan Ashwell, Lynsie Almeida et al. · Journal of Medicinal Chemistry · 2012 · 70 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +16

Pyrimidinone Nicotinamide Mimetics as Selective Tankyrase and Wnt Pathway Inhibitors Suitable for in Vivo Pharmacology

Jeffrey W. Johannes, Lynsie Almeida, Bernard Barlaam et al. · ACS Medicinal Chemistry Letters · 2015 · 65 citations

Medicine, Oncology, Pharmacology +14

Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering

Jeffrey W. Johannes, Lynsie Almeida, Kevin Daly et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 63 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +6

Discovery of 1-Methyl-1<i>H</i>-imidazole Derivatives as Potent Jak2 Inhibitors

Qibin Su, Stephanos Ioannidis, Claudio Chuaqui et al. · Journal of Medicinal Chemistry · 2013 · 56 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13