Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Shih-Min A. Huang, Yuji Mishina, Shanming Liu et al. · Nature · 2009 · 2.1K citations

Life Sciences, Biochemistry, Cell Biology +10

(2<i>R</i>)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-<i>a</i>]pyrazin- 7(8<i>H</i>)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine:  A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Dooseop Kim, Liping Wang, Maria Beconi et al. · Journal of Medicinal Chemistry · 2004 · 817 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

Mijung Kwon, Susana A. Godinho, Namrata S. Chandhok et al. · Genes & Development · 2008 · 665 citations · Full text

Life Sciences, Cell Biology, Oncology +17

4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2<i>H</i>-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1

Keith Menear, Claire Adcock, Robert Boulter et al. · Journal of Medicinal Chemistry · 2008 · 586 citations · Full text

Medicine, Oncology, Pharmacology +16

Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function

Paul Chang, Margaret Coughlin, Timothy J. Mitchison · Nature Cell Biology · 2005 · 263 citations

Life Sciences, Biochemistry, Molecular Biology +7