Huiping Guan

SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity

Shem Patyna, Alexander Laird, Dirk B. Mendel et al. · Molecular Cancer Therapeutics · 2006 · 102 citations

Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering

Jeffrey W. Johannes, Lynsie Almeida, Kevin Daly et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 62 citations · Full text

Medicine, Natural Sciences, Molecular Biology +5

Design and synthesis of aminopropyl tetrahydroindole-based indolin-2-ones as selective and potent inhibitors of Src and Yes tyrosine kinase

Huiping Guan, Alexander Laird, Robert A. Blake et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 55 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Biochemistry +10

Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS

Hilary S. Eidam, John P. Russell, Kaushik Raha et al. · ACS Medicinal Chemistry Letters · 2018 · 32 citations · Full text

Replacement of pyrazol-3-yl amine hinge binder with thiazol-2-yl amine: Discovery of potent and selective JAK2 inhibitors

Stephanos Ioannidis, Michelle L. Lamb, Lynsie Almeida et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 25 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +12