Dirk B. Mendel

In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship.

Dirk B. Mendel, Alexander Laird, Xiaohua Xin et al. · PubMed · 2003 · 2K citations

Tumor Xenografts, Mouse Xenograft Models, Active Dose +18

Influenza Neuraminidase Inhibitors Possessing a Novel Hydrophobic Interaction in the Enzyme Active Site:  Design, Synthesis, and Structural Analysis of Carbocyclic Sialic Acid Analogues with Potent Anti-Influenza Activity

Choung U. Kim, Willard Lew, Matthew A. Williams et al. · Journal of the American Chemical Society · 1997 · 1.1K citations

BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription

Paul A. Khavari, Craig L. Peterson, John W. Tamkun et al. · Nature · 1993 · 678 citations

Chromatin, Transcriptional Regulation, Cell Regulation +11

A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo.

James G. Christensen, Randall Schreck, Jon Burrows et al. · PubMed · 2003 · 497 citations

Cancer Biology, Tumor Biology, C-met Kinase +20

The H274Y mutation in the influenza A/H1N1 neuraminidase active site following oseltamivir phosphate treatment leave virus severely compromised both in vitro and in vivo

J. Ives, Jackie Carr, Dirk B. Mendel et al. · Antiviral Research · 2002 · 380 citations

Viral Evolution, Molecular Virology, Pathogenesis +7