Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

Travis K. Warren, Robert Jordan, Michael K. Lo, +59

Nature

Small Molecule Gs-5734Rhesus MonkeysMedicineViral PathogenesisImmunology +8

Influenza Neuraminidase Inhibitors Possessing a Novel Hydrophobic Interaction in the Enzyme Active Site:  Design, Synthesis, and Structural Analysis of Carbocyclic Sialic Acid Analogues with Potent Anti-Influenza Activity

Choung U. Kim, Willard Lew, Matthew A. Williams, +9

Journal of the American Chemical Society

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-<i>f</i>][triazin-4-amino] Adenine <i>C</i>-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

Dustin S. Siegel, Hon C. Hui, Edward Doerffler, +30

Journal of Medicinal Chemistry

Structure−Activity Relationship Studies of Novel Carbocyclic Influenza Neuraminidase Inhibitors

Choung U. Kim, Willard Lew, Matthew A. Williams, +7

Journal of Medicinal Chemistry

Oral Administration of a Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071 Protects Mice and Ferrets against Influenza Infection

Dirk B. Mendel, Chun Y. Tai, Paul A. Escarpe, +13

Antimicrobial Agents and Chemotherapy

Identification of GS 4104 as an Orally Bioavailable Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071

Weixing Li, Paul A. Escarpe, Eugene Eisenberg, +11

Antimicrobial Agents and Chemotherapy

VaccinationMedicineGs 4071Antiviral Drug DevelopmentAntiviral Therapy +9

Practical Total Synthesis of the Anti-Influenza Drug GS-4104

John C. Rohloff, Kenneth M. Kent, Michael J. Postich, +10

The Journal of Organic Chemistry

Medicinal ChemistryMolecular SciencesPharmaceutical ChemistryPractical Total SynthesisMedicine +10

Characterization of Human Influenza Virus Variants Selected In Vitro in the Presence of the Neuraminidase Inhibitor GS 4071

Chun Y. Tai, Paul A. Escarpe, Robert W. Sidwell, +5

Antimicrobial Agents and Chemotherapy

Discovery of the First <i>C</i>-Nucleoside HCV Polymerase Inhibitor (GS-6620) with Demonstrated Antiviral Response in HCV Infected Patients

Aesop Cho, Lijun Zhang, Jie Xu, +21

Journal of Medicinal Chemistry

Viral Polymerase StructureAdenosine AnalogsHepatitis C VirusImmunologyPharmacotherapy +15

Discovery of a potent and selective Aurora kinase inhibitor

Johan D. Oslob, M.J. Romanowski, Darin A. Allen, +25

Bioorganic & Medicinal Chemistry Letters

Signaling PathwayReceptor Tyrosine KinaseMedicineCell BiologyCell Signaling +2