Hon C. Hui

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

Travis K. Warren, Robert Jordan, Michael K. Lo et al. · Nature · 2016 · 1.6K citations · Full text

Small Molecule Gs-5734, Rhesus Monkeys, Medicine +10

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-<i>f</i>][triazin-4-amino] Adenine <i>C</i>-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

Dustin S. Siegel, Hon C. Hui, Edward Doerffler et al. · Journal of Medicinal Chemistry · 2017 · 648 citations · Full text

GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses

Michael K. Lo, Robert Jordan, Aaron Arvey et al. · Scientific Reports · 2017 · 504 citations · Full text

Development of Serine Protease Inhibitors Displaying a Multicentered Short (&lt;2.3 Å) Hydrogen Bond Binding Mode:  Inhibitors of Urokinase-Type Plasminogen Activator and Factor Xa

Erik Verner, B.A. Katz, Jeffrey R. Spencer et al. · Journal of Medicinal Chemistry · 2001 · 124 citations · Full text

Drug Target, Bioorganic Chemistry, Serine Protease Inhibitors +19

Discovery of an Oral Respiratory Syncytial Virus (RSV) Fusion Inhibitor (GS-5806) and Clinical Proof of Concept in a Human RSV Challenge Study

Richard L. Mackman, Michael Sangi, David Sperandio et al. · Journal of Medicinal Chemistry · 2015 · 120 citations

Immunology, Pharmacology, Rsv Infection +12