Development of Serine Protease Inhibitors Displaying a Multicentered Short (<2.3 Å) Hydrogen Bond Binding Mode:  Inhibitors of Urokinase-Type Plasminogen Activator and Factor Xa

Erik Verner, B.A. Katz, Jeffrey R. Spencer, +17

Journal of Medicinal Chemistry

Drug TargetBioorganic ChemistrySerine Protease InhibitorsChemical BiologyNovel Scaffolds +17

A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site11Edited by D. Rees

B.A. Katz, Kyle Elrod, Christine Luong, +12

Journal of Molecular Biology

Protein AssemblyBiochemistryProtein FoldingD. ReesNatural Sciences +7

Comparative study of methods to couple hindered peptides

Jeffrey R. Spencer, Valery V. Antonenko, Nancy G. J. Delaet, +1

International journal of peptide & protein research

Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets

B.A. Katz, Paul A. Sprengeler, Christine Luong, +11

Chemistry & Biology

Protease InhibitorsProtein FunctionDrug TargetDrug TargetingBiochemistry +8

Antitumor activity of tetrahydroisoquinoline analogues 3-epi-jorumycin and 3-epi-renieramycin G

Jonathan W. Lane, Alberto Estevez, Kyle Mortara, +3

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryAntitumor ActivityMedicineAntimicrobial ChemotherapyAnti-cancer Agent +3

Highly potent non-peptidic inhibitors of the HCV NS3/NS4A serine protease

David Sperandio, Anthony R. Gangloff, Joane Litvak, +14

Bioorganic & Medicinal Chemistry Letters

Protease InhibitorsBiochemistryMedicineAntiviral Drug DevelopmentAntiviral Therapy +5

Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-directed Serine Protease Inhibitors

B.A. Katz, Kyle Elrod, Erik Verner, +12

Journal of Molecular Biology

Protein ChemistryProtein AssemblyBiochemistryProtein FoldingNatural Sciences +6

Factors Related to the Sensitivity of Emergency Medical Service Impression of Stroke

Toby Gropen, Reshma Gokaldas, Rebecca Poleshuck, +5

Prehospital Emergency Care

2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors

Richard L. Mackman, Hon C. Hui, J. Guy Breitenbucher, +11

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesMechanism Of Action +7

Cyclic hexapeptide analogs of somatostatin containing bridge modifications

Ziwei Huang, Albert Pröbstl, Jeffrey R. Spencer, +2

International journal of peptide & protein research