GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

Robin A. Aglietti, Alberto Estevez, Aaron Gupta, +6

Proceedings of the National Academy of Sciences

Proteinlipid InteractionPyroptosis FormsApoptosisImmunologyGsdmd P30 +19

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist

Shivani Ahuja, Susmith Mukund, Lunbin Deng, +32

Science

Voltage-gated SodiumMolecular BiologyMolecular PharmacologyIsoform SelectivityInhibitory Activity +16

Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab

Lionel Rougé, Nancy Chiang, Micah Steffek, +12

Science

Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin

Hui Xu, Tianbo Li, Alexis Rohou, +11

Cell

Nav1.7 InhibitionMolecular PhysiologyToxinologyBiochemistryNatural Sciences +6

An In Vivo Human-Plasmablast Enrichment Technique Allows Rapid Identification of Therapeutic Influenza A Antibodies

Gerald Nakamura, Ning Chai, Summer Park, +14

Cell Host & Microbe

VaccinationImmunocytochemical TechniqueImmunologyVirologyAntibody Screening +5

Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6

Eric Bourhis, Weiru Wang, Christine Tam, +14

Structure

Signal TransductionBiochemistryMedicinePeptide LibraryPeptide Therapeutic +8

Battling Btk Mutants With Noncovalent Inhibitors That Overcome Cys481 and Thr474 Mutations

Adam R. Johnson, Pawan Bir Kohli, Arna Katewa, +18

ACS Chemical Biology

Thr474 MutationsDrug TargetTyrosine KinaseMolecular BiologyBtk Mutants +16

Molecular basis for negative regulation of the glucagon receptor

Christopher M. Koth, Jeremy Murray, Susmith Mukund, +11

Proceedings of the National Academy of Sciences

Crystal StructureMolecular PhysiologySignal TransductionBiochemistryGlucagon Receptor Inhibition +13

A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment

Alessia Balestrini, Victory Joseph, Michelle Dourado, +57

The Journal of Experimental Medicine

InflammationAsthmaTrpa1 InhibitorAnti-inflammatoryInflammatory Lung Disease +13

Expression, Crystallization, and Three-dimensional Structure of the Catalytic Domain of Human Plasma Kallikrein

Jie Tang, Christine Yu, Steven R. Williams, +10

Journal of Biological Chemistry

Catalytic DomainProtein AssemblyGlycobiologyMolecular BiologyProtein Purification +16