Structure of C3b in complex with CRIg gives insights into regulation of complement activation

Christian Wiesmann, Kenneth J. Katschke, Jianping Yin, +8

Nature

Complement SystemProtein FunctionSignal TransductionMolecular RegulationCell Signaling +10

Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab

Lionel Rougé, Nancy Chiang, Micah Steffek, +12

Science

An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance

Thijs J. Hagenbeek, Marc Hafner, Rana Mroue, +38

Nature Cancer

Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling

Jeffrey K. Holden, James J. Crawford, Cameron L. Noland, +17

Cell Reports

Lipid PeroxidationLipid TailTumor BiologyOxidative StressInflammation +15

ATP-Dependent <scp>l</scp>-Cysteine:1<scp>d</scp>-<i>myo</i>-Inosityl 2-Amino-2-deoxy-α-<scp>d</scp>-glucopyranoside Ligase, Mycothiol Biosynthesis Enzyme MshC, Is Related to Class I Cysteinyl-tRNA Synthetases

Dipti Sareen, Micah Steffek, Gerald L. Newton, +1

Biochemistry

Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization

Nicholas P. D. Liau, Timothy J. Wendorff, John G. Quinn, +10

Nature Structural & Molecular Biology

14-3-3-Induced DimerizationSignal TransductionRaf Kinase ActivityCell RegulationMolecular Regulation +11

A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis

Kenneth J. Katschke, Karim Y. Helmy, Micah Steffek, +12

The Journal of Experimental Medicine

Crystal StructureComplement Reverses InflammationComplement PathwaysImmunologyImmunologic Mechanism +22

Identification of Imidazo-Pyrrolopyridines as Novel and Potent JAK1 Inhibitors

Janusz J. Kulagowski, Wade Blair, Richard J. Bull, +27

Journal of Medicinal Chemistry

RheumatologyMedicinal ChemistryDrug TargetBiochemistryMedicine +13

Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design

Xiaojing Wang, Steven Magnuson, Rich Pastor, +12

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ScienceProperty-based Drug DesignBiochemistryPotent Pan-pim Inhibitors +8

Characterization of <i>Mycobacterium tuberculosis</i> Mycothiol <i>S</i>-Conjugate Amidase

Micah Steffek, Gerald L. Newton, Yossef Av‐Gay, +1

Biochemistry

Pulmonary TuberculosisBiochemistryNatural SciencesMetalloproteinMycothiol S-conjugate +9