Christian Wiesmann

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

Ingrid E. Wertz, Karen O’Rourke, Honglin Zhou et al. · Nature · 2004 · 1.8K citations

Signal Transduction, Cell Regulation, Molecular Pathway +11

The Identification of 2-(1<i>H</i>-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-<i>d</i>]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer

Adrian Folkes, Khatereh Ahmadi, W. Alderton et al. · Journal of Medicinal Chemistry · 2008 · 739 citations · Full text

Pi3 Kinase, Chemoprevention Strategy, Pharmacotherapy +18

Allosteric inhibition of protein tyrosine phosphatase 1B

Christian Wiesmann, Kenneth J. Barr, Jenny Kung et al. · Nature Structural & Molecular Biology · 2004 · 519 citations

Allosteric Inhibition, Signal Transduction, Biochemistry +5

Crystal Structure at 1.7 Å Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor

Christian Wiesmann, Germaine Fuh, Hans W. Christinger et al. · Cell · 1997 · 481 citations · Full text

Crystal Structure, Signal Transduction, Signaling Pathway +9

Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured fab in complex with antigen 1 1Edited by I. A. Wilson

Yvonne Chen, Christian Wiesmann, Germaine Fuh et al. · Journal of Molecular Biology · 1999 · 446 citations

Crystal Structure, Affinity-matured Fab, Immunology +6