W. Alderton

Nitric oxide synthases: structure, function and inhibition

W. Alderton, Chris E. Cooper, Richard G. Knowles · Biochemical Journal · 2001 · 2.6K citations

Bioorganic Chemistry, Enzyme Family, Biochemistry +14

The Identification of 2-(1<i>H</i>-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-<i>d</i>]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer

Adrian Folkes, Khatereh Ahmadi, W. Alderton et al. · Journal of Medicinal Chemistry · 2008 · 739 citations · Full text

Pi3 Kinase, Chemoprevention Strategy, Pharmacotherapy +18

Zebrafish based assays for the assessment of cardiac, visual and gut function — potential safety screens for early drug discovery

Stéphane Berghmans, Paul Butler, Paul Goldsmith et al. · Journal of Pharmacological and Toxicological Methods · 2008 · 187 citations

Animal Testing, Preclinical Drug Evaluation, Medicine +8

Evaluation of serum CEA, CYFRA21-1 and CA125 for the early detection of colorectal cancer using longitudinal preclinical samples

Darren Thomas, E‐O Fourkala, Sophia Apostolidou et al. · British Journal of Cancer · 2015 · 129 citations · Full text

Accumulation and metabolism of drugs and CYP probe substrates in zebrafish larvae

W. Alderton, Stéphane Berghmans, Paul Butler et al. · Xenobiotica · 2010 · 109 citations