Yvonne Chen

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

Jagath R. Junutula, Helga Raab, Suzanna Clark et al. · Nature Biotechnology · 2008 · 1.4K citations

Pharmacy, Pharmaceutics, Pharmacology +16

Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured fab in complex with antigen 1 1Edited by I. A. Wilson

Yvonne Chen, Christian Wiesmann, Germaine Fuh et al. · Journal of Molecular Biology · 1999 · 447 citations

Pharmacy, Medicinal Chemistry, Molecular Biology +14

Anti-CD20/CD3 T cell–dependent bispecific antibody for the treatment of B cell malignancies

Liping Sun, Diego Ellerman, Mary Mathieu et al. · Science Translational Medicine · 2015 · 278 citations

Life Sciences, Hematology, Immunology +11

Therapeutic potential of an anti-CD79b antibody–drug conjugate, anti–CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma

David Dornan, Fiona Bennett, Yvonne Chen et al. · Blood · 2009 · 271 citations · Full text

Pharmacy, Oncology, Pharmacology +17

VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 å resolution and mutational analysis of the interface

Yves A. Muller, Yvonne Chen, Hans W. Christinger et al. · Structure · 1998 · 265 citations · Full text

Pharmacy, Molecular Biology, Antibody Engineering +15