Edward Doerffler

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

Travis K. Warren, Robert Jordan, Michael K. Lo et al. · Nature · 2016 · 1.6K citations · Full text

Life Sciences, Infectious Diseases, Microbiology +17

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-<i>f</i>][triazin-4-amino] Adenine <i>C</i>-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

Dustin S. Siegel, Hon C. Hui, Edward Doerffler et al. · Journal of Medicinal Chemistry · 2017 · 665 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of the First <i>C</i>-Nucleoside HCV Polymerase Inhibitor (GS-6620) with Demonstrated Antiviral Response in HCV Infected Patients

Aesop Cho, Lijun Zhang, Jie Xu et al. · Journal of Medicinal Chemistry · 2013 · 128 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Nucleotide Prodrug GS-5734 Is a Broad-Spectrum Filovirus Inhibitor That Provides Complete Therapeutic Protection Against the Development of Ebola Virus Disease (EVD) in Infected Non-human Primates

Travis K. Warren, Robert Jordan, Michale Lo et al. · Open Forum Infectious Diseases · 2015 · 63 citations · Full text

Pharmacy, Infectious Diseases, Infectious Disease Pharmacotherapy +12

Discovery of GS-9256: A novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity

X. Christopher Sheng, Anthony Casarez, Ruby Cai et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 48 citations

Medicine, Infectious Diseases, Medicinal Chemistry +12