Dustin S. Siegel

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

Timothy P. Sheahan, Amy Sims, Rachel L. Graham et al. · Science Translational Medicine · 2017 · 1.6K citations · Full text

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

Travis K. Warren, Robert Jordan, Michael K. Lo et al. · Nature · 2016 · 1.6K citations · Full text

Small Molecule Gs-5734, Rhesus Monkeys, Medicine +10

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

Maria L. Agostini, Erica L. Andres, Amy Sims et al. · mBio · 2018 · 1.5K citations · Full text

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-<i>f</i>][triazin-4-amino] Adenine <i>C</i>-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

Dustin S. Siegel, Hon C. Hui, Edward Doerffler et al. · Journal of Medicinal Chemistry · 2017 · 648 citations · Full text

GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses

Michael K. Lo, Robert Jordan, Aaron Arvey et al. · Scientific Reports · 2017 · 504 citations · Full text