Structural basis for RNA replication by the hepatitis C virus polymerase

T.C. Appleby, Jason K. Perry, Eisuke Murakami, +10

Science

Viral ReplicationRna ReplicationViral Polymerase StructureViral Polymerase MechanismMolecular Biology +17

Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

Aesop Cho, Oliver L. Saunders, Thomas Butler, +6

Bioorganic & Medicinal Chemistry Letters

1′-Substituted 4-Aza-7,9-dideazaadenosine C-nucleosidesBiochemistryAntiviral ActivityAntiviral Drug DevelopmentAntiviral Therapy +4

Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides

Jamie J. Arnold, Suresh D. Sharma, Joy Y. Feng, +16

PLoS Pathogens

Discovery of the First <i>C</i>-Nucleoside HCV Polymerase Inhibitor (GS-6620) with Demonstrated Antiviral Response in HCV Infected Patients

Aesop Cho, Lijun Zhang, Jie Xu, +21

Journal of Medicinal Chemistry

Viral Polymerase StructureAdenosine AnalogsHepatitis C VirusImmunologyPharmacotherapy +15

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 3: Optimization of potency in the pyridopyrimidine series through the application of a pharmacophore model

Kiyoshi Nakayama, Haruko C. Kawato, Jun Watanabe, +14

Bioorganic & Medicinal Chemistry Letters

Pyridopyrimidine SeriesAntimicrobial SusceptibilityMedicinePseudomonas AeruginosaAntibacterial Agent +7

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 4: Addressing the problem of poor stability due to photoisomerization of an acrylic acid moiety

Kiyoshi Nakayama, Noriko Kuru, Masami Ohtsuka, +14

Bioorganic & Medicinal Chemistry Letters

Acrylic Acid MoietyAntimicrobial SusceptibilityAntibioticsPseudomonas AeruginosaAntimicrobial Chemotherapy +7

Discovery of GS-9256: A novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity

X. Christopher Sheng, Anthony Casarez, Ruby Cai, +13

Bioorganic & Medicinal Chemistry Letters

Novel Phosphinic AcidBiochemistryViral HepatitisDrug DiscoveryPotent Clinical Activity +8

Practical synthesis of 1′-substituted Tubercidin C-nucleoside analogs

Sammy Metobo, Jie Xu, Oliver L. Saunders, +4

Tetrahedron Letters

Practical SynthesisOrganic ChemistryChemistryNatural Product SynthesisSynthetic Chemistry

Metabolism and Pharmacokinetics of the Anti-Hepatitis C Virus Nucleotide Prodrug GS-6620

Eisuke Murakami, Ting Wang, Darius Babusis, +10

Antimicrobial Agents and Chemotherapy

Oral BioavailabilityImmunologyAntiviral DrugViral HepatitisBioanalysis +18

Discovery of GS-9451: An acid inhibitor of the hepatitis C virus NS3/4A protease

X. Christopher Sheng, T.C. Appleby, Thomas Butler, +14

Bioorganic & Medicinal Chemistry Letters

BiochemistryViral HepatitisNatural SciencesAntiviral Drug DevelopmentHepatitis +6