T.C. Appleby

Clinical targeting of HIV capsid protein with a long-acting small molecule

John O. Link, Martin S. Rhee, Winston C. Tse et al. · Nature · 2020 · 392 citations · Full text

Natural Sciences, Human Retrovirus, Immunology +10

Structural basis for RNA replication by the hepatitis C virus polymerase

T.C. Appleby, Jason K. Perry, Eisuke Murakami et al. · Science · 2015 · 344 citations

Viral Replication, Rna Replication, Viral Polymerase Structure +19

RDEA119/BAY 869766: A Potent, Selective, Allosteric Inhibitor of MEK1/2 for the Treatment of Cancer

Cory Iverson, Gary Larson, Chon Lai et al. · Cancer Research · 2009 · 182 citations · Full text

Chemoprevention Strategy, Cell Proliferation, Tumor Biology +20

Identification and structure–activity relationships of substituted pyridones as inhibitors of Pim-1 kinase

I. Wayne Cheney, Shunqi Yan, T.C. Appleby et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 170 citations · Full text

Substituted Pyridones, Molecular Pharmacology, Medicinal Chemistry +15

The crystal structure and mechanism of orotidine 5′-monophosphate decarboxylase

T.C. Appleby, Cynthia Kinsland, Tadhg P. Begley et al. · Proceedings of the National Academy of Sciences · 2000 · 161 citations