The H274Y mutation in the influenza A/H1N1 neuraminidase active site following oseltamivir phosphate treatment leave virus severely compromised both in vitro and in vivo

Statistical Method in Biological Assay.

M. J. R. Healy, D. J. Finney · Journal of the Royal Statistical Society Series A (General) · 1979 · 3.6K citations

Education, Biostatistics, Statistics +8

Influenza Neuraminidase Inhibitors Possessing a Novel Hydrophobic Interaction in the Enzyme Active Site:  Design, Synthesis, and Structural Analysis of Carbocyclic Sialic Acid Analogues with Potent Anti-Influenza Activity

Choung U. Kim, Willard Lew, Matthew A. Williams et al. · Journal of the American Chemical Society · 1997 · 1.1K citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Fluorometric assay of neuraminidase with a sodium (4-methylumbelliferyl-α-d-N-acetylneuraminate) substrate

M. Potier, L. Mameli, M. Bélisle et al. · Analytical Biochemistry · 1979 · 824 citations

Life Sciences, Pharmaceutical Analysis, Enzymology +4

Oral oseltamivir treatment of influenza in children

Richard J. Whitley, Frederick G. Hayden, Keith S. Reisinger et al. · The Pediatric Infectious Disease Journal · 2001 · 717 citations

Pharmacy, Pediatrics, Pharmacotherapy +13

Use of the Oral Neuraminidase Inhibitor Oseltamivir in Experimental Human Influenza

Frederick G. Hayden, John J. Treanor, Richard Fritz et al. · JAMA · 1999 · 558 citations

Medicine, Pharmacology, Pharmacotherapy +16