Gaochao Tian

Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency

Philip D. Edwards, Jeffrey S. Albert, Mark Sylvester et al. · Journal of Medicinal Chemistry · 2007 · 211 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Relationships between Biomarkers of Exposure and Neurological Effects in a Group of Workers Exposed to Acrylamide

Carl Johan Calleman, Yuehui Wu, Feilong He et al. · Toxicology and Applied Pharmacology · 1994 · 178 citations

Pharmacy, Neurology, Toxicology +12

Linear Non-competitive Inhibition of Solubilized Human γ-Secretase by Pepstatin A Methylester, L685458, Sulfonamides, and Benzodiazepines

Gaochao Tian, Cynthia D. Sobotka‐Briner, John R. Zysk et al. · Journal of Biological Chemistry · 2002 · 146 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Oxygen-18 kinetic isotope effects in the dopamine .beta.-monooxygenase reaction: Evidence for a new chemical mechanism in non-heme, metallomonooxygenase

Gaochao Tian, Joseph A. Berry, Judith P. Klinman · Biochemistry · 1994 · 110 citations

Life Sciences, Biochemistry, Chemistry +16

The Mechanism of γ-Secretase

Gaochao Tian, Smita V. Ghanekar, David Aharony et al. · Journal of Biological Chemistry · 2003 · 77 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17