Philip D. Edwards

Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency

Philip D. Edwards, Jeffrey S. Albert, Mark Sylvester et al. · Journal of Medicinal Chemistry · 2007 · 211 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of a Novel Warhead against β-Secretase through Fragment-Based Lead Generation

Stefan Geschwindner, Lise‐Lotte Olsson, Jeffrey S. Albert et al. · Journal of Medicinal Chemistry · 2007 · 148 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Linear Non-competitive Inhibition of Solubilized Human γ-Secretase by Pepstatin A Methylester, L685458, Sulfonamides, and Benzodiazepines

Gaochao Tian, Cynthia D. Sobotka‐Briner, John R. Zysk et al. · Journal of Biological Chemistry · 2002 · 146 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Design, synthesis, and kinetic evaluation of a unique class of elastase inhibitors, the peptidyl .alpha.-ketobenzoxazoles, and the x-ray crystal structure of the covalent complex between porcine pancreatic elastase and Ac-Ala-Pro-Val-2-benzoxazole

Philip D. Edwards, Edgar F. Meyer, J. Vijayalakshmi et al. · Journal of the American Chemical Society · 1992 · 144 citations

Pharmacy, Chemistry, Pharmacology +10

Application of Fragment Screening by X-ray Crystallography to the Discovery of Aminopyridines as Inhibitors of β-Secretase

Miles Congreve, David Aharony, Jeffrey S. Albert et al. · Journal of Medicinal Chemistry · 2007 · 143 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +17