Stefan Geschwindner

Structural insight into allosteric modulation of protease-activated receptor 2

R.K. Cheng, Cédric Fiez-Vandal, Oliver Schlenker et al. · Nature · 2017 · 253 citations

Life Sciences, Biochemistry, Molecular Biology +16

Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency

Philip D. Edwards, Jeffrey S. Albert, Mark Sylvester et al. · Journal of Medicinal Chemistry · 2007 · 211 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of a Novel Warhead against β-Secretase through Fragment-Based Lead Generation

Stefan Geschwindner, Lise‐Lotte Olsson, Jeffrey S. Albert et al. · Journal of Medicinal Chemistry · 2007 · 148 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints

K. A. P. Edman, Ali Hosseini, Magnus Bjursell et al. · Structure · 2015 · 110 citations · Full text

Life Sciences, Biochemistry, Evolutionary Biology +17

Crystal structure of microsomal prostaglandin E ₂ synthase provides insight into diversity in the MAPEG superfamily

Tove Sjögren, Johan Nord, Margareta Ek et al. · Proceedings of the National Academy of Sciences · 2013 · 98 citations · Full text

Life Sciences, Biochemistry, Pharmacology +11