Glutamate 286 in Cytochrome <i>aa</i>₃ from <i>Rhodobacter </i><i>sphaeroides</i> Is Involved in Proton Uptake during the Reaction of the Fully-Reduced Enzyme with Dioxygen

Pia Ädelroth, Margareta Ek, David M. Mitchell, +2

Biochemistry

MraY–antibiotic complex reveals details of tunicamycin mode of action

Jonna Hakulinen, Jenny Hering, Gisela Brändén, +4

Nature Chemical Biology

Antimicrobial Drug DiscoveryAntibioticsMedicineTunicamycin ModeAntimicrobial Chemotherapy +7

Crystal structure of microsomal prostaglandin E₂synthase provides insight into diversity in the MAPEG superfamily

Tove Sjögren, Johan Nord, Margareta Ek, +3

Proceedings of the National Academy of Sciences

Factors determining electron-transfer rates in cytochrome c oxidase: investigation of the oxygen reaction in the R. sphaeroides enzyme

Pia Ädelroth, Margareta Ek, Peter Brzezinski

Biochimica et Biophysica Acta (BBA) - Bioenergetics

BiochemistryBioelectrochemistryBioenergeticsNatural SciencesOxygen Reaction +7

Aminoimidazoles as BACE-1 inhibitors: The challenge to achieve in vivo brain efficacy

Britt‐Marie Swahn, Jörg Holenz, Jacob Kihlström, +14

Bioorganic & Medicinal Chemistry Letters

MedicinePharmacologyBace-1 InhibitorsPharmacological AgentNeuropharmacology +8

Affinity maturation of a novel antagonistic human monoclonal antibody with a long V_HCDR3 targeting the Class A GPCR formyl-peptide receptor 1

Julie A. Douthwaite, Sudharsan Sridharan, Catherine Huntington, +16

mAbs

Peptide EngineeringImmunologyFpro0165 FabPeptide TherapeuticsImmunotherapy +14

Oxidation of Ubiquinol by Cytochrome <i>bo</i>₃ from <i>Escherichia coli</i>:  Kinetics of Electron and Proton Transfer

Margareta Ek, Peter Brzezinski

Biochemistry

EngineeringBioelectrochemistryChemical BiologyRedox BiologyHerbicide Hqno +14

Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism

Lena Ripa, Jenny Sandmark, Glyn A. Hughes, +14

Journal of Medicinal Chemistry

Chemoprevention StrategySubstrate InhibitorsTheir Bioactivation MechanismHdac FamilyChemical Biology +20

Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1<i>S</i>,2<i>S</i>)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma

Magnus Munck af Rosenschöld, Petra Johannesson, Antonios Nikitidis, +24

Journal of Medicinal Chemistry

Exploring the Active Site of the Antibacterial Target MraY by Modified Tunicamycins

Jenny Hering, Elin Dunevall, Arjan Snijder, +8

ACS Chemical Biology

Antimicrobial ChemotherapyChemical BiologyAntibiotic ResistanceDrug ResistanceMolecular Pharmacology +21