John I. Manchester

A New-Class Antibacterial—Almost. Lessons in Drug Discovery and Development: A Critical Analysis of More than 50 Years of Effort toward ATPase Inhibitors of DNA Gyrase and Topoisomerase IV

Gregory S. Bisacchi, John I. Manchester · ACS Infectious Diseases · 2014 · 180 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +16

A New Mechanistic Probe for Cytochrome P450:  An Application of Isotope Effect Profiles

John I. Manchester, Joseph P. Dinnocenzo, Higgins et al. · Journal of the American Chemical Society · 1997 · 131 citations

Medicine, Chemistry, Pharmacology +12

Evaluation of p<i>K</i>_a Estimation Methods on 211 Druglike Compounds

John I. Manchester, Grant K. Walkup, Olga Rivin et al. · Journal of Chemical Information and Modeling · 2010 · 110 citations

Pharmacy, Chemistry, Medicinal Chemistry +17

Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV

John I. Manchester, Daemian D. Dussault, Jonathan A. Rose et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 88 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +13

Optimization of Pyrrolamide Topoisomerase II Inhibitors Toward Identification of an Antibacterial Clinical Candidate (AZD5099)

Gregory S. Basarab, Pamela Hill, C. Edwin Garner et al. · Journal of Medicinal Chemistry · 2014 · 81 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17