John I. Manchester

A New-Class Antibacterial—Almost. Lessons in Drug Discovery and Development: A Critical Analysis of More than 50 Years of Effort toward ATPase Inhibitors of DNA Gyrase and Topoisomerase IV

Gregory S. Bisacchi, John I. Manchester · ACS Infectious Diseases · 2014 · 176 citations

Antibiotic Adjuvant, Antimicrobial Chemotherapy, Drug Resistance +19

A New Mechanistic Probe for Cytochrome P450:  An Application of Isotope Effect Profiles

John I. Manchester, Joseph P. Dinnocenzo, Higgins et al. · Journal of the American Chemical Society · 1997 · 131 citations

Chemical Analysis, Altmetric Attention Score, Molecular Biology +25

Evaluation of p<i>K</i>_a Estimation Methods on 211 Druglike Compounds

John I. Manchester, Grant K. Walkup, Olga Rivin et al. · Journal of Chemical Information and Modeling · 2010 · 106 citations

Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV

John I. Manchester, Daemian D. Dussault, Jonathan A. Rose et al. · Bioorganic & Medicinal Chemistry Letters · 2012 · 88 citations · Full text

Medicinal Chemistry, Biochemistry, Natural Sciences +9

Fragment-to-Hit-to-Lead Discovery of a Novel Pyridylurea Scaffold of ATP Competitive Dual Targeting Type II Topoisomerase Inhibiting Antibacterial Agents

Gregory S. Basarab, John I. Manchester, Shanta Bist et al. · Journal of Medicinal Chemistry · 2013 · 79 citations · Full text

Bioorganic Chemistry, Antibacterial Activity, Antimicrobial Chemotherapy +24