Vincent M. Isabella

Activated ClpP kills persisters and eradicates a chronic biofilm infection

Brian P. Conlon, Ernesto Nakayasu, L Fleck et al. · Nature · 2013 · 662 citations · Full text

Antimicrobial Susceptibility, Microbiology, Infection Control +5

Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria

Vincent M. Isabella, Binh Ha, Mary Joan Castillo et al. · Nature Biotechnology · 2018 · 548 citations

Biosynthesis, Engineering, Biotechnology +6

An engineered <i>E. coli</i> Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans

Caroline Kurtz, Yves Millet, Marja Puurunen et al. · Science Translational Medicine · 2019 · 366 citations

Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study

Marja Puurunen, Jerry Vockley, Shawn Searle et al. · Nature Metabolism · 2021 · 146 citations

Engineering, Medicine, First-in-human Phase 1/2A +8

Improvement of a synthetic live bacterial therapeutic for phenylketonuria with biosensor-enabled enzyme engineering

Kristin J. Adolfsen, Isolde Callihan, Catherine Monahan et al. · Nature Communications · 2021 · 91 citations · Full text