Synlogic (United States)

Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria

Vincent M. Isabella, Binh Ha, Mary Joan Castillo et al. · Nature Biotechnology · 2018 · 548 citations

Biosynthesis, Engineering, Biotechnology +6

Metabolic modulation of tumours with engineered bacteria for immunotherapy

Fernando P. Canale, Camilla Basso, Gaia Antonini et al. · Nature · 2021 · 541 citations

Cancer Immunosurveillance, Engineered Bacteria, Medicine +6

Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity

Daniel S. Leventhal, Anna Sokolovska, Ning Li et al. · Nature Communications · 2020 · 410 citations · Full text

An engineered <i>E. coli</i> Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans

Caroline Kurtz, Yves Millet, Marja Puurunen et al. · Science Translational Medicine · 2019 · 366 citations

Acetyl-CoA carboxylase inhibition disrupts metabolic reprogramming during hepatic stellate cell activation

Jamie Bates, Archana Vijayakumar, Sarani Ghoshal et al. · Journal of Hepatology · 2020 · 215 citations · Full text