Aoife M. Brennan

Phase 3 study of recombinant factor VIII Fc fusion protein in severe hemophilia A

Johnny Mahlangu, Jerry S. Powell, Margaret V. Ragni et al. · Blood · 2013 · 441 citations · Full text

Medicine, Hematology, Molecular Biology +14

An engineered <i>E. coli</i> Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans

Caroline Kurtz, Yves Millet, Marja Puurunen et al. · Science Translational Medicine · 2019 · 392 citations

Life Sciences, Biological Engineering, Biotechnology +12

Phase 3 Study of Recombinant Factor IX Fc Fusion Protein in Hemophilia B

Jerry S. Powell, John Pasi, Margaret V. Ragni et al. · New England Journal of Medicine · 2013 · 352 citations · Full text

Medicine, Hematology, Immunology +14

Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study

Marja Puurunen, Jerry Vockley, Shawn Searle et al. · Nature Metabolism · 2021 · 160 citations

Engineering, Biological Engineering, Biotechnology +5

Phase I Study of SYNB1891, an Engineered <i>E. coli</i> Nissle Strain Expressing STING Agonist, with and without Atezolizumab in Advanced Malignancies

Jason J. Luke, Sarina A. Piha‐Paul, Theresa Medina et al. · Clinical Cancer Research · 2023 · 145 citations · Full text

Life Sciences, Immunology, Oncology +17