William S. Denney

An engineered <i>E. coli</i> Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans

Caroline Kurtz, Yves Millet, Marja Puurunen et al. · Science Translational Medicine · 2019 · 392 citations

Life Sciences, Biological Engineering, Biotechnology +12

Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study

Marja Puurunen, Jerry Vockley, Shawn Searle et al. · Nature Metabolism · 2021 · 160 citations

Engineering, Biological Engineering, Biotechnology +5

Systems Biology of Coagulation Initiation: Kinetics of Thrombin Generation in Resting and Activated Human Blood

Manash Chatterjee, William S. Denney, Huiyan Jing et al. · PLoS Computational Biology · 2010 · 154 citations · Full text

Medicine, Hematology, Systems Biology +17

Determination of surface tissue factor thresholds that trigger coagulation at venous and arterial shear rates: amplification of 100 fM circulating tissue factor requires flow

Uzoma M. Okorie, William S. Denney, Manash Chatterjee et al. · Blood · 2008 · 132 citations · Full text

Engineering, Biomedical Engineering, Physiology +14

AKR-001, an Fc-FGF21 Analog, Showed Sustained Pharmacodynamic Effects on Insulin Sensitivity and Lipid Metabolism in Type 2 Diabetes Patients

Allegra Kaufman, Lubna Abuqayyas, William S. Denney et al. · Cell Reports Medicine · 2020 · 125 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +14