“Selective” Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu5 Allosteric Ligands

Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator

Huixian Wu, Chong Wang, Karen J. Gregory et al. · Science · 2014 · 547 citations

Life Sciences, Molecular Biology, Pharmacology +17

CPCCOEt, a Noncompetitive Metabotropic Glutamate Receptor 1 Antagonist, Inhibits Receptor Signaling Without Affecting Glutamate Binding

Stephane Litschig, F. Gasparini, D Rueegg et al. · Molecular Pharmacology · 1999 · 343 citations

Life Sciences, Neuroscience, Pharmacology +16

Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment

Michael J. Marino, David L. Williams, Julie A. O’Brien et al. · Proceedings of the National Academy of Sciences · 2003 · 237 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Calcilytic Compounds: Potent and Selective Ca2+Receptor Antagonists That Stimulate Secretion of Parathyroid Hormone

Edward F. Nemeth, Eric G. DelMar, William L. Heaton et al. · Journal of Pharmacology and Experimental Therapeutics · 2001 · 234 citations

Medicine, Endocrinology, Pharmacology +17

Allosteric Modulation of Seven Transmembrane Spanning Receptors: Theory, Practice, and Opportunities for Central Nervous System Drug Discovery

Bruce J. Melancon, Corey R. Hopkins, Michael R. Wood et al. · Journal of Medicinal Chemistry · 2011 · 223 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17