Concepedia

Cooperativity

Cooperativity is a kinetic phenomenon in enzyme-substrate interactions wherein the binding of a ligand to one active site of a multimeric enzyme induces conformational changes that alter the binding affinity of other active sites, thereby enhancing or reducing subsequent ligand binding in a non-independent manner.

2.9K

Publications

166.6K

Citations

10.2K

Authors

2K

Institutions

Publications per year

2017–2026

491

Parents

Publications

2.9K

The microRNA.org resource: targets and expression

Doron Betel, Michael T. Wilson, Aaron Gabow et al. · Nucleic Acids Research · 2007 · 2.6K citations · Full text

, , +16

Stability of proteins. Proteins which do not present a single cooperative system.

Peter L. Privalov · PubMed · 1982 · 1K citations

, , +10

The Hill equation revisited: uses and misuses

James N. Weiss · The FASEB Journal · 1997 · 1K citations

, , +16

High Cooperativity in Coupled Microwave Resonator Ferrimagnetic Insulator Hybrids

Hans Huebl, Christoph W. Zollitsch, Johannes Lotze et al. · Physical Review Letters · 2013 · 885 citations · Full text

, , +17

What is Cooperativity?

Christopher A. Hunter, Harry L. Anderson · Angewandte Chemie International Edition · 2009 · 794 citations

, , +17

1–5 of 2.9K

Authors

10.2K

  1. JR
    James R. Halpert

    University of Arizona, United States

    14 publications · 827 citations

    14

    h-index

  2. PD
    Pierre De Meyts

    Novo Nordisk (Denmark), Denmark

    14 publications · 2.2K citations

    14

    h-index

  3. JE
    José Elguero

    Instituto de Química Médica, Spain

    14 publications · 886 citations

    13

    h-index

  4. MD
    Mehdi D. Esrafili

    University of Maragheh, Iran

    15 publications · 424 citations

    13

    h-index

  5. IA
    Ibón Alkorta

    Instituto de Química Médica, Spain

    15 publications · 931 citations

    13

    h-index

1–5 of 10.2K

Institutions

2K

  1. Centre National de la Recherche Scientifique

    Paris, France

    42 h-index

    398 publications

    24.9K citations

  2. National Institutes of Health

    Bethesda, United States

    33 h-index

    149 publications

    15.4K citations

  3. University of California, Berkeley

    Berkeley, United States

    26 h-index

    100 publications

    11.1K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    25 h-index

    69 publications

    6.8K citations

  5. University of California San Diego

    San Diego, United States

    24 h-index

    90 publications

    6.2K citations

  6. Harvard University

    Cambridge, United States

    23 h-index

    83 publications

    14.6K citations

  7. Washington University in St. Louis

    St Louis, United States

    23 h-index

    113 publications

    4.8K citations

  8. Stanford University

    Stanford, United States

    23 h-index

    94 publications

    6.8K citations

1–8 of 2K

Venues

  1. Journal of Biological Chemistry

    JBC · 315 publications · 20.1K citations

    76

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 147 publications · 12.9K citations

    66

    h-index

  3. Journal of the American Chemical Society

    JACS · 111 publications · 10K citations

    61

    h-index

  4. Biochemistry

    222 publications · 10.2K citations

    52

    h-index

  5. European Journal of Biochemistry

    EJB · 101 publications · 3.7K citations

    33

    h-index

1–5