BCR-ABL1 Compound Mutations Combining Key Kinase Domain Positions Confer Clinical Resistance to Ponatinib in Ph Chromosome-Positive Leukemia

Matthew S. Zabriskie, Christopher A. Eide, Srinivas K. Tantravahi, +39

Cancer Cell

Hematological MalignancyPh Chromosome-positive LeukemiaGeneticsMolecular GeneticsCancer Genetics +5

Calcilytic Compounds: Potent and Selective Ca2+Receptor Antagonists That Stimulate Secretion of Parathyroid Hormone

Edward F. Nemeth, Eric G. DelMar, William L. Heaton, +7

Journal of Pharmacology and Experimental Therapeutics

Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia

Anna M. Eiring, Brent D. G. Page, Ira L. Kraft, +23

Leukemia

Hematological MalignancyMedicineMixed-phenotype Acute LeukemiaMalignant Blood DisorderPharmacology +6

SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia

Dongqing Yan, Anca Franzini, Anthony D. Pomicter, +28

Blood Cancer Discovery

Autocrine Tnf signaling favors malignant cells in myelofibrosis in a Tnfr2-dependent fashion

William L. Heaton, Anna V. Senina, Anthony D. Pomicter, +8

Leukemia

3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis

I. M. Shcherbakova, Manuel F. Balandrin, John Fox, +3

Bioorganic & Medicinal Chemistry Letters

Bone DiseaseMedicinal ChemistryBone HealthMedicineOsteoarthritis +6

shRNA library screening identifies nucleocytoplasmic transport as a mediator of BCR-ABL1 kinase-independent resistance

Jamshid S. Khorashad, Anna M. Eiring, Clinton C. Mason, +18

Blood

Discovery and characterization of AZD9272 and AZD6538—Two novel mGluR5 negative allosteric modulators selected for clinical development

Patrick Raboisson, Anna Breitholtz‐Emanuelsson, Henrik Dahllöf, +15

Bioorganic & Medicinal Chemistry Letters

Negative Allosteric ModulatorsMolecular PharmacologyG Protein-coupled ReceptorMedicineDrug Discovery +4

Nuclear–Cytoplasmic Transport Is a Therapeutic Target in Myelofibrosis

Dongqing Yan, Anthony D. Pomicter, Srinivas K. Tantravahi, +23

Clinical Cancer Research

Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer

Andrew E. Shouksmith, Fenil Shah, Michelle Grimard, +17

Journal of Medicinal Chemistry

Hdac InhibitorsPathologyHdac DrugCancer BiologyTumor Biology +14