Combining the Allosteric Inhibitor Asciminib with Ponatinib Suppresses Emergence of and Restores Efficacy against Highly Resistant BCR-ABL1 Mutants

Christopher A. Eide, Matthew S. Zabriskie, Samantha L. Savage, +21

Cancer Cell

Allosteric Inhibitor AsciminibMedicineImmunologyPharmacotherapyPonatinib Suppresses Emergence +6

Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia

Anna M. Eiring, Brent D. G. Page, Ira L. Kraft, +23

Leukemia

Hematological MalignancyMedicineMixed-phenotype Acute LeukemiaMalignant Blood DisorderPharmacology +6

A Small-Molecule Inhibitor of PIM Kinases as a Potential Treatment for Urothelial Carcinomas

Jason M. Foulks, Kent J. Carpenter, Bai Luo, +22

Neoplasia

Pharmacologic Activation of PKM2 Slows Lung Tumor Xenograft Growth

K. Mark Parnell, Jason M. Foulks, Rebecca N. Nix, +16

Molecular Cancer Therapeutics

SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia

Dongqing Yan, Anca Franzini, Anthony D. Pomicter, +28

Blood Cancer Discovery

Autocrine Tnf signaling favors malignant cells in myelofibrosis in a Tnfr2-dependent fashion

William L. Heaton, Anna V. Senina, Anthony D. Pomicter, +8

Leukemia

Oncolysis by paramyxoviruses: preclinical and clinical studies

O. V. Matveeva, Zong Sheng Guo, Vyacheslav M Senin, +3

Molecular Therapy — Oncolytics

Nuclear–Cytoplasmic Transport Is a Therapeutic Target in Myelofibrosis

Dongqing Yan, Anthony D. Pomicter, Srinivas K. Tantravahi, +23

Clinical Cancer Research

MS4A3 promotes differentiation in chronic myeloid leukemia by enhancing common β-chain cytokine receptor endocytosis

Helong Zhao, Anthony D. Pomicter, Anna M. Eiring, +25

Blood

Hematological MalignancyTranscriptional RegulationChronic Myeloid LeukemiaCell RegulationImmune Cell Development +13

Loss of G0/G1 switch gene 2 (G0S2) promotes disease progression and drug resistance in chronic myeloid leukaemia (CML) by disrupting glycerophospholipid metabolism

Mayra A. Gonzalez, Idaly M. Olivas, Alfonso E. Bencomo‐Alvarez, +27

Clinical and Translational Medicine