Concepedia

Modulator Selectivity

Modulator Selectivity is a pharmacological property denoting the specificity of an allosteric modulator for a particular receptor subtype or conformational state, distinguishing it from other modulators by its selective binding and functional effects within a given receptor system.

138

Publications

9.1K

Citations

954

Authors

343

Institutions

Publications per year

2017–2026

40

Parents

Publications

138

Abatacept for Rheumatoid Arthritis Refractory to Tumor Necrosis Factor α Inhibition

Mark C. Genovese, Jean‐Claude Becker, Michael Schiff et al. · New England Journal of Medicine · 2005 · 1.2K citations · Full text

, , +16

Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: Twelve‐month results of a phase iib, double‐blind, randomized, placebo‐controlled trial

Joel M. Kremer, Maxime Dougados, Paul Emery et al. · Arthritis & Rheumatism · 2005 · 446 citations · Full text

, , +16

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

Saibal Dey, Murali Ramachandra, Ira Pastan et al. · Proceedings of the National Academy of Sciences · 1997 · 336 citations

, , +14

Identification of a New Modulator of the Intercalated Disc in a Zebrafish Model of Arrhythmogenic Cardiomyopathy

Angeliki Asimaki, Sudhir Kapoor, Eva Plovie et al. · Science Translational Medicine · 2014 · 274 citations

, , +13

Structural basis for the specific inhibition of heterotrimeric G <sub>q</sub> protein by a small molecule

Akiyuki Nishimura, Ken Kitano, Jun Takasaki et al. · Proceedings of the National Academy of Sciences · 2010 · 256 citations

, , +17

1–5 of 138

Authors

954

  1. MF
    Marcus F. Boehm

    Ligand Pharmaceuticals (United States), United States

    3 publications · 164 citations

    3

    h-index

  2. SC
    Sylvain Chemtob

    Centre Hospitalier Universitaire Sainte-Justine, Canada

    3 publications · 66 citations

    3

    h-index

  3. SV
    Suresh V. Ambudkar

    National Cancer Institute, United States

    3 publications · 406 citations

    3

    h-index

  4. WD
    William D. Lubell

    Université de Montréal, Canada

    3 publications · 66 citations

    3

    h-index

  5. DA
    Dale A. Mais

    Ligand Pharmaceuticals (United States), United States

    2 publications · 53 citations

    2

    h-index

1–5 of 954

Institutions

343

  1. National Institutes of Health

    Bethesda, United States

    4 h-index

    10 publications

    1.8K citations

  2. Inserm

    Paris, France

    4 h-index

    9 publications

    712 citations

  3. Johns Hopkins Medicine

    Baltimore, United States

    3 h-index

    5 publications

    1.2K citations

  4. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    4 publications

    125 citations

  5. Monash University

    Melbourne, Australia

    3 h-index

    20 publications

    842 citations

  6. University of California San Diego

    San Diego, United States

    3 h-index

    6 publications

    310 citations

  7. University of Alabama at Birmingham

    Birmingham, United States

    3 h-index

    7 publications

    984 citations

  8. National Cancer Institute

    Bethesda, United States

    3 h-index

    8 publications

    1.8K citations

1–8 of 343

Venues

  1. Journal of Medicinal Chemistry

    9 publications · 339 citations

    9

    h-index

  2. Molecular Pharmacology

    9 publications · 503 citations

    9

    h-index

  3. PubMed

    Repository · 7 publications · 228 citations

    7

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 6 publications · 1K citations

    6

    h-index

  5. Journal of Biological Chemistry

    JBC · 6 publications · 364 citations

    6

    h-index

1–5