Concepedia

Gpcr Selectivity

GPCR Selectivity is a pharmacological property that refers to the capacity of a ligand to preferentially bind to or activate a specific G protein-coupled receptor subtype over other structurally or functionally related GPCR subtypes.

181

Publications

12.9K

Citations

1.3K

Authors

363

Institutions

Publications per year

2017–2026

71

Variants

G Protein-coupled Receptor Selectivity

Parents

Publications

181

Illuminating G-Protein-Coupling Selectivity of GPCRs

Asuka Inoue, Francesco Raimondi, Francois Marie Ngako Kadji et al. · Cell · 2019 · 679 citations · Full text

, , +8

G‐protein‐coupled receptors: molecular mechanisms involved in receptor activation and selectivity of G‐protein recognition

Jürgen Wess · The FASEB Journal · 1997 · 592 citations

, , +17

Selectivity determinants of GPCR–G-protein binding

Tilman Flock, Alexander S. Hauser, Nadia Lund et al. · Nature · 2017 · 399 citations · Full text

, , +14

N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor

Douglas McHugh, Sherry S-J. Hu, Neta Rimmerman et al. · BMC Neuroscience · 2010 · 318 citations · Full text

, , +15

PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

Hsin‐Yung Yen, Kin Kuan Hoi, Idlir Liko et al. · Nature · 2018 · 310 citations · Full text

, , +14

1–5 of 181

Authors

1.3K

  1. GM
    Graeme Milligan

    University of Glasgow, United Kingdom

    10 publications · 497 citations

    10

    h-index

  2. DE
    David E. Gloriam

    University of Copenhagen, Denmark

    10 publications · 1.2K citations

    10

    h-index

  3. MB
    Michel Bouvier

    Université de Montréal, Canada

    9 publications · 784 citations

    9

    h-index

  4. AS
    Alexander S. Hauser

    University of Copenhagen, Denmark

    6 publications · 752 citations

    6

    h-index

  5. AI
    Asuka Inoue

    Tohoku University, Japan

    5 publications · 1K citations

    5

    h-index

1–5 of 1.3K

Institutions

363

  1. University of Copenhagen

    Copenhagen, Denmark

    14 h-index

    43 publications

    4.3K citations

  2. Université de Montréal

    Montreal, Canada

    11 h-index

    52 publications

    4.8K citations

  3. University of Glasgow

    Glasgow, United Kingdom

    11 h-index

    47 publications

    2.5K citations

  4. Institute for Research in Immunology and Cancer

    Montreal, Canada

    10 h-index

    49 publications

    4.8K citations

  5. Inserm

    Paris, France

    8 h-index

    16 publications

    1.3K citations

  6. National Institute of Diabetes and Digestive and Kidney Diseases

    Bethesda, United States

    6 h-index

    28 publications

    2.7K citations

  7. Pfizer (United States)

    New York, United States

    6 h-index

    66 publications

    2.2K citations

  8. Tohoku University

    Sendai, Japan

    6 h-index

    18 publications

    7.3K citations

1–8 of 363

Venues

  1. Journal of Medicinal Chemistry

    17 publications · 977 citations

    15

    h-index

  2. Journal of Biological Chemistry

    JBC · 8 publications · 693 citations

    8

    h-index

  3. Molecular Pharmacology

    7 publications · 322 citations

    7

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 7 publications · 510 citations

    7

    h-index

  5. Journal of Chemical Information and Modeling

    JCIM · 5 publications · 150 citations

    5

    h-index

1–5