Concepedia

Recombinant human IgG1 based Fc multimers, with limited FcR binding capacity, can effectively inhibit complement-mediated disease

Haoping Sun, Henrik S. Olsen, Emmanuel Y. Mérigeon, Edward So, Erin Burch, Susan Kinsey, John C. Papadimitriou, Cinthia B. Drachenberg, Søren M. Bentzen, David S. Block,

Journal of Autoimmunity · 2017 · 18 citations · 24 references

DOI

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References

24

High Resolution Mapping of the Binding Site on Human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and Design of IgG1 Variants with Improved Binding to the FcγR

Robert L. Shields, Angela K. Namenuk, Kyu Hong et al. · Journal of Biological Chemistry · 2001 · 1.2K citations · Full text

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Engineered antibody Fc variants with enhanced effector function

Greg A. Lazar, Wei Dang, Sher Karki et al. · Proceedings of the National Academy of Sciences · 2006 · 794 citations · Full text

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Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

Christoph A. Diebolder, Frank J. Beurskens, Rob N. de Jong et al. · Science · 2014 · 784 citations

, , +14

Engineered Fc variant antibodies with enhanced ability to recruit complement and mediate effector functions

Gregory L. Moore, Hsing Chen, Sher Karki et al. · mAbs · 2010 · 257 citations · Full text

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Opsonization of Apoptotic Cells by Autologous iC3b Facilitates Clearance by Immature Dendritic Cells, Down-regulates DR and CD86, and Up-regulates CC Chemokine Receptor 7

Inna Verbovetski, Hila Bychkov, Uriel Trahtemberg et al. · The Journal of Experimental Medicine · 2002 · 255 citations · Full text

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