Concepedia

Fc Engineering

Fc Engineering is a specialized area of antibody engineering that involves the targeted modification of the fragment crystallizable (Fc) region of immunoglobulins to optimize effector functions, serum half-life, and immune system engagement.

330

Publications

21.7K

Citations

2.3K

Authors

581

Institutions

Publications per year

2017–2026

110

Variants

Fc-engineering

Parents

Children

Publications

330

Engineered antibody Fc variants with enhanced effector function

Greg A. Lazar, Wei Dang, Sher Karki et al. · Proceedings of the National Academy of Sciences · 2006 · 794 citations · Full text

, , +17

An Fc receptor structurally related to MHC class I antigens

Neil E. Simister, Keith E. Mostov · Nature · 1989 · 718 citations

, , +13

FcγRIV: A Novel FcR with Distinct IgG Subclass Specificity

Falk Nimmerjahn, Pierre Bruhns, Ken Horiuchi et al. · Immunity · 2005 · 654 citations · Full text

, , +7

THE CONCEPT OF FGM

Masashi Koizumi · Ceramic transactions /Ceramic transactions · 1993 · 641 citations

, , +1

Broadly Neutralizing Anti-HIV-1 Antibodies Require Fc Effector Functions for In Vivo Activity

Stylianos Bournazos, Florian Klein, John Pietzsch et al. · Cell · 2014 · 504 citations · Full text

, , +10

1–5 of 330

Authors

2.3K

  1. MP
    Matthias Peipp

    Christian-Albrechts-Universität zu Kiel, Germany

    13 publications · 770 citations

    12

    h-index

  2. JR
    John R. Desjarlais

    Xencor (United States), United States

    10 publications · 1.1K citations

    10

    h-index

  3. TV
    Thomas Valerius

    Christian-Albrechts-Universität zu Kiel, Germany

    10 publications · 456 citations

    10

    h-index

  4. CK
    Christian Kellner

    Christian-Albrechts-Universität zu Kiel, Germany

    10 publications · 371 citations

    10

    h-index

  5. JV
    Jeffrey V. Ravetch

    Rockefeller University, United States

    8 publications · 1.7K citations

    8

    h-index

1–5 of 2.3K

Institutions

581

  1. Christian-Albrechts-Universität zu Kiel

    Kiel, Germany

    13 h-index

    94 publications

    4.2K citations

  2. Xencor (United States)

    Monrovia, United States

    12 h-index

    94 publications

    20.6K citations

  3. Amgen (United States)

    Thousand Oaks, United States

    11 h-index

    75 publications

    8K citations

  4. Oslo University Hospital

    Oslo, Norway

    8 h-index

    40 publications

    2.1K citations

  5. The University of Texas at Austin

    Austin, United States

    8 h-index

    50 publications

    4.8K citations

  6. Rockefeller University

    New York, United States

    8 h-index

    31 publications

    7.8K citations

  7. University of Oslo

    Oslo, Norway

    8 h-index

    42 publications

    2.5K citations

  8. Chugai Pharma (United States)

    Berkeley Heights, United States

    7 h-index

    47 publications

    5.4K citations

1–8 of 581

Venues

  1. mAbs

    21 publications · 1.3K citations

    17

    h-index

  2. Molecular Immunology

    18 publications · 673 citations

    14

    h-index

  3. Blood

    10 publications · 754 citations

    10

    h-index

  4. Journal of Biological Chemistry

    JBC · 10 publications · 891 citations

    10

    h-index

  5. Protein Engineering Design and Selection

    PEDS · 10 publications · 1.3K citations

    10

    h-index

1–5