John R. Desjarlais

Enhanced antibody half-life improves in vivo activity

Jonathan Zalevsky, Aaron K. Chamberlain, Holly M. Horton et al. · Nature Biotechnology · 2010 · 644 citations · Full text

Pharmacy, Immunology, Pharmacokinetics +12

De novo design of the hydrophobic cores of proteins

John R. Desjarlais, Tracy M. Handel · Protein Science · 1995 · 307 citations · Full text

Life Sciences, Bioinformatics, Biology +15

Optimization of antibody binding to FcγRIIa enhances macrophage phagocytosis of tumor cells

John O. Richards, Sher Karki, Greg A. Lazar et al. · Molecular Cancer Therapeutics · 2008 · 304 citations

Life Sciences, Cell Biology, Immunology +17

Potent <i>In vitro</i> and <i>In vivo</i> Activity of an Fc-Engineered Anti-CD19 Monoclonal Antibody against Lymphoma and Leukemia

Holly M. Horton, Matthew J. Bernett, Erik Pong et al. · Cancer Research · 2008 · 271 citations · Full text

Pharmacy, Immunology, Oncology +17

Inactivation of TNF Signaling by Rationally Designed Dominant-Negative TNF Variants

Paul M. Steed, Malú G. Tansey, Jonathan Zalevsky et al. · Science · 2003 · 259 citations

Life Sciences, Immunology, Molecular Biology +17