Engineered antibody Fc variants with enhanced effector function

Greg A. Lazar, Wei Dang, Sher Karki, +11

Proceedings of the National Academy of Sciences

Engineered Fc RegionsNovel TherapyAntibody Fc VariantsMedicineImmunology +11

Enhanced antibody half-life improves in vivo activity

Jonathan Zalevsky, Aaron K. Chamberlain, Holly M. Horton, +6

Nature Biotechnology

Antibody Half-life ImprovesImmunologyAntibody ScreeningAutoimmunityImmunochemistry +3

Optimization of antibody binding to FcγRIIa enhances macrophage phagocytosis of tumor cells

John O. Richards, Sher Karki, Greg A. Lazar, +3

Molecular Cancer Therapeutics

Engineered Fc variant antibodies with enhanced ability to recruit complement and mediate effector functions

Gregory L. Moore, Hsing Chen, Sher Karki, +1

mAbs

De novo design of the hydrophobic core of ubiquitin

Greg A. Lazar, John R. Desjarlais, Tracy M. Handel

Protein Science

Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcγRIIb with Fc-engineered antibodies

Seung Y. Chu, Igor Voštiar, Sher Karki, +6

Molecular Immunology

Adaptive Immune SystemImmune Cell DevelopmentHumoral ResponseImmune RegulationImmunology +11

A molecular immunology approach to antibody humanization and functional optimization

Greg A. Lazar, John R. Desjarlais, Jonathan Jacinto, +2

Molecular Immunology

EngineeringMedicineImmunoengineeringImmunologyAntibody Screening +8

A novel bispecific antibody format enables simultaneous bivalent and monovalent co-engagement of distinct target antigens

Gregory L. Moore, Cristina Bautista, Erik Pong, +7

mAbs

ImmunologyImmunodominanceAntigen ProcessingImmunotherapeuticsImmunotherapy +14

Solution structure and dynamics of a designed hydrophobic core variant of ubiquitin

Eric C. Johnson, Greg A. Lazar, John R. Desjarlais, +1

Structure

Protein ChemistrySolution StructureProtein FoldingMolecular BiologyStructural Biology +4

Biochemical and Structural Studies of the Interaction of Cdc37 with Hsp90

Wei Zhang, Miriam Hirshberg, Stephen H. McLaughlin, +7

Journal of Molecular Biology

Protein FunctionBiochemistryBiomolecular Structure PredictionNatural SciencesProtein X-ray Crystallography +4