Optimization of antibody binding to FcγRIIa enhances macrophage phagocytosis of tumor cells

John O. Richards, Sher Karki, Greg A. Lazar, +3

Molecular Cancer Therapeutics

Engineered Fc variant antibodies with enhanced ability to recruit complement and mediate effector functions

Gregory L. Moore, Hsing Chen, Sher Karki, +1

mAbs

Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody

Seung Y. Chu, Holly M. Horton, Erik Pong, +9

Journal of Allergy and Clinical Immunology

Fc-engineered AntibodyTargeted CoengagementImmunologyImmunodominanceAntibody Screening +10

Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies

Holly M. Horton, Matthew J. Bernett, Matthias Peipp, +8

Blood

Suppression of Rheumatoid Arthritis B Cells by XmAb5871, an Anti‐CD19 Antibody That Coengages B Cell Antigen Receptor Complex and Fcγ Receptor IIb Inhibitory Receptor

Seung Y. Chu, Karen Yeter, Roshan Kotha, +10

Arthritis & Rheumatology

Engineering Fully Human Monoclonal Antibodies from Murine Variable Regions

Matthew J. Bernett, Sher Karki, Gregory L. Moore, +9

Journal of Molecular Biology

Immunocytochemical TechniqueMedicineMurine Variable RegionsImmunologyAntibody Screening +5

Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function

Yu‐Tzu Tai, Holly M. Horton, Sun‐Young Kong, +12

Blood

ImmunologyImmune RegulationImmunoeditingImmunologic MechanismBiological Therapy +18

Immunotherapy with Long-Lived Anti-CD123 × Anti-CD3 Bispecific Antibodies Stimulates Potent T Cell-Mediated Killing of Human AML Cell Lines and of CD123+ Cells in Monkeys: A Potential Therapy for Acute Myelogenous Leukemia

Seung Y. Chu, Erik Pong, Hsing Chen, +11

Blood

Tuning T Cell Affinity Improves Efficacy and Safety of Anti-CD38 × Anti-CD3 Bispecific Antibodies in Monkeys - a Potential Therapy for Multiple Myeloma

Gregory L. Moore, Sung‐Hyung Lee, Suzanne Schubbert, +15

Blood

Immune suppression in cynomolgus monkeys by XPro9523

Matthew J. Bernett, Seung Y. Chu, Irene Leung, +10

mAbs

Laboratory ImmunologyInnate Immune SystemImmunologyImmunologic MechanismAntigen Processing +14