Concepedia

Complement Activation Engineering

Complement Activation Engineering is a methodological framework within Fc engineering that specifically modulates the interaction between the Fc region of antibodies and complement proteins to enhance or suppress the activation of the complement cascade in a targeted immunotherapeutic context.

6

Publications

346

Citations

44

Authors

23

Institutions

Publications per year

2017–2026

2

Parents

Publications

6

Complement activation cascade triggered by PEG–PL engineered nanomedicines and carbon nanotubes: The challenges ahead

S. Moein Moghimi, Alina J. Andersen, Sayed Hossein Hashemi et al. · Journal of Controlled Release · 2010 · 165 citations

, , +15

Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking

Linping Wu, Mario Ficker, Jørn B. Christensen et al. · Nature Communications · 2021 · 45 citations · Full text

, , +17

Engineering of recombinant soluble CD46: an inhibitor of complement activation.

Dale Christiansen, Julie Milland, Bruce Thorley et al. · PubMed · 1996 · 42 citations

, , +16

Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H–like Protein 1 Reveal Functional Determinants of Complement Regulation

Markus J. Harder, Markus Anliker, Britta Höchsmann et al. · The Journal of Immunology · 2015 · 38 citations · Full text

, , +14

Engineering Intravenously Administered Nanoparticles to Reduce Infusion Reaction and Stop Bleeding in a Large Animal Model of Trauma

Chimdiya Onwukwe, Nuzhat Maisha, Mark Holland et al. · Bioconjugate Chemistry · 2018 · 35 citations

, , +17

1–5 of 6

Authors

44

  1. SM
    S. Moein Moghimi

    University of Copenhagen, Denmark

    2 publications · 210 citations

    2

    h-index

  2. ES
    Edzard Spillner

    Universität Hamburg, Germany

    1 publications · 21 citations

    1

    h-index

  3. AJ
    Andrew J. Shoffstall

    Case Western Reserve University, United States

    1 publications · 35 citations

    1

    h-index

  4. PN
    Panagiotis N. Trohopoulos

    Cosmote (Greece), Greece

    1 publications · 45 citations

    1

    h-index

  5. TL
    Thomas L. Andresen

    Technical University of Denmark, Denmark

    1 publications · 165 citations

    1

    h-index

1–5 of 44

Institutions

23

  1. University of Copenhagen

    Copenhagen, Denmark

    2 h-index

    9 publications

    1K citations

  2. Technische Hochschule Ulm

    Ulm, Germany

    1 h-index

    4 publications

    152 citations

  3. German Red Cross

    Berlin, Germany

    1 h-index

    3 publications

    114 citations

  4. University of Brighton

    Brighton, United Kingdom

    1 h-index

    1 publications

    165 citations

  5. Universität Ulm

    Ulm, Germany

    1 h-index

    7 publications

    266 citations

  6. Lemuel Shattuck Hospital

    Jamaica Plain, United States

    1 h-index

    1 publications

    35 citations

  7. Chinese Academy of Sciences

    Beijing, China

    1 h-index

    1 publications

    45 citations

  8. Harvard University

    Cambridge, United States

    1 h-index

    1 publications

    35 citations

1–8 of 23

Venues

  1. Bioconjugate Chemistry

    1 publications · 35 citations

    1

    h-index

  2. The Journal of Immunology

    JI · 1 publications · 38 citations

    1

    h-index

  3. Journal of Controlled Release

    1 publications · 165 citations

    1

    h-index

  4. PubMed

    Repository · 1 publications · 42 citations

    1

    h-index

  5. Immunology Letters

    1 publications · 21 citations

    1

    h-index

1–5