Concepedia

Fc Disulfide Engineering

Fc Disulfide Engineering is a protein engineering methodology within the field of immunoglobulin Fc region optimization that specifically involves the strategic modification of disulfide bond architecture to enhance structural stability, modulate effector functions, and improve the biophysical properties of therapeutic antibodies.

5

Publications

137

Citations

30

Authors

7

Institutions

Publications per year

2017–2026

2

Variants

Fc Disulfide Bond Engineering

Parents

Publications

5

Preparation and characterization of a disulfide-stabilized Fv fragment of the anti-Tac antibody: Comparison with its single-chain analog

Keith O. Webber · Molecular Immunology · 1995 · 48 citations

, , +10

Improvement of Fc–erythropoietin structure and pharmacokinetics by modification at a disulfide bond

Jeffrey C. Way, Scott Lauder, Beatrice Brunkhorst et al. · Protein Engineering Design and Selection · 2005 · 39 citations

, , +17

Enabling the formation of native mAb, Fab′ and Fc-conjugates using a bis-disulfide bridging reagent to achieve tunable payload-to-antibody ratios (PARs)

Fabien Thoreau, Léa N. C. Rochet, James R. Baker et al. · Chemical Science · 2023 · 19 citations · Full text

, , +17

Comprehensive elucidation of the structural and functional roles of engineered disulfide bonds in antibody Fc fragment

Fang Zeng, Xinyu Gao, Xuan Li et al. · Journal of Biological Chemistry · 2018 · 16 citations · Full text

, , +17

An Engineered Disulfide Bond Reversibly Traps the IgE-Fc3–4 in a Closed, Nonreceptor Binding Conformation

Beth A. Wurzburg, Beomkyu Kim, Svetlana S. Tarchevskaya et al. · Journal of Biological Chemistry · 2012 · 15 citations · Full text

, , +16

1–5 of 5

Authors

30

  1. JR
    James R. Baker

    University College London, United Kingdom

    1 publications · 19 citations

    1

    h-index

  2. ZZ
    Zhe Zhang

    Chinese Academy of Sciences, China

    1 publications · 16 citations

    1

    h-index

  3. YL
    Yan Lan

    Ono Pharmaceutical (United States), United States

    1 publications · 39 citations

    1

    h-index

  4. VC
    Vijay Chudasama

    University College London, United Kingdom

    1 publications · 19 citations

    1

    h-index

  5. IC
    Islay Campbell

    University of Liège, Belgium

    1 publications · 39 citations

    1

    h-index

1–5 of 30

Institutions

7

  1. University College London

    London, United Kingdom

    1 h-index

    4 publications

    76 citations

  2. University of Bern

    Bern, Switzerland

    1 h-index

    2 publications

    30 citations

  3. University of Chinese Academy of Sciences

    Beijing, China

    1 h-index

    3 publications

    48 citations

  4. Wuhan Institute of Virology

    Wuhan, China

    1 h-index

    6 publications

    96 citations

  5. National Cancer Institute

    Bethesda, United States

    1 h-index

    1 publications

    48 citations

  6. Stanford University

    Stanford, United States

    1 h-index

    4 publications

    60 citations

  7. Chinese Academy of Sciences

    Beijing, China

    1 h-index

    6 publications

    96 citations

1–7 of 7

Venues

  1. Journal of Biological Chemistry

    JBC · 2 publications · 31 citations

    2

    h-index

  2. Protein Engineering Design and Selection

    PEDS · 1 publications · 39 citations

    1

    h-index

  3. Chemical Science

    1 publications · 19 citations

    1

    h-index

  4. Molecular Immunology

    1 publications · 48 citations

    1

    h-index

1–4