Allosteric Fc Modulation is a methodological approach in Fc engineering that selectively alters the conformational dynamics of the Fc region of antibodies through distal binding interactions, thereby modulating effector functions without direct engagement of the Fc's active sites.
4
Publications
259
Citations
29
Authors
16
Institutions
Publications per year
2017–2026
4
Parents
Publications
4
Extending human IgG half-life using structure-guided design
Brian J. Booth, Boopathy Ramakrishnan, Kristin Narayan et al. · mAbs · 2018 · 111 citations · Full text
Antigen binding allosterically promotes Fc receptor recognition
Jun Zhao, Ruth Nussinov, Buyong Ma · mAbs · 2018 · 77 citations · Full text
FcγRIIB-I232T polymorphic change allosterically suppresses ligand binding
Wei Hu, Yong Zhang, Xiaolin Sun et al. · eLife · 2019 · 28 citations · Full text
1–4 of 4
Authors
29
- PL
1
h-index
- DD
1
h-index
- AM
1
h-index
- BJBrian J. Booth
University of Massachusetts Chan Medical School, United States
1 publications · 111 citations
1
h-index
- GJGregory J. Babcock
University of Massachusetts Chan Medical School, United States
1 publications · 111 citations
1
h-index
1–5 of 29
Institutions
16
Institute of Biophysics
Beijing, China
1 h-index
2 publications
56 citations
University of Maryland, Baltimore
Baltimore, United States
1 h-index
9 publications
387 citations
University of Chinese Academy of Sciences
Beijing, China
1 h-index
1 publications
28 citations
State Key Laboratory of Modern Optical Instruments
Hangzhou, China
1 h-index
1 publications
28 citations
Chinese Academy of Sciences
Beijing, China
1 h-index
2 publications
56 citations
Institute of Human Virology
Abuja, Nigeria
1 h-index
1 publications
43 citations
Tel Aviv University
Tel Aviv, Israel
1 h-index
1 publications
77 citations
Tsinghua University
Beijing, China
1 h-index
3 publications
84 citations
1–8 of 16