Concepedia

Fc Multimerization

Fc Multimerization is a biochemical engineering strategy involving the controlled assembly of multiple Fc domains into higher-order oligomeric structures to enhance effector functions, valency, or stability in therapeutic antibodies.

35

Publications

2K

Citations

267

Authors

82

Institutions

Publications per year

2017–2026

12

Parents

Publications

35

Proinflammatory IgG Fc structures in patients with severe COVID-19

Saborni Chakraborty, Joseph C. González, Karlie Edwards et al. · Nature Immunology · 2020 · 324 citations · Full text

, , +13

Enhancing Antibody Fc Heterodimer Formation through Electrostatic Steering Effects

Kannan Gunasekaran, Martin Pentony, Min Shen et al. · Journal of Biological Chemistry · 2010 · 284 citations · Full text

, , +17

Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy

Irfan Ullah, Jérémie Prévost, Mark S. Ladinsky et al. · Immunity · 2021 · 237 citations · Full text

, , +13

SEEDbodies: fusion proteins based on strand-exchange engineered domain (SEED) CH3 heterodimers in an Fc analogue platform for asymmetric binders or immunofusions and bispecific antibodies†

Jonathan H. Davis, Christel Aperlo, Yue Li et al. · Protein Engineering Design and Selection · 2010 · 189 citations · Full text

, , +17

Analytical characterization of biosimilar antibodies and Fc-fusion proteins

Alain Beck, Hélène Diemer, Daniel Ayoub et al. · TrAC Trends in Analytical Chemistry · 2013 · 117 citations

, , +16

1–5 of 35

Authors

267

  1. ES
    Edward So

    University of Maryland, Baltimore, United States

    3 publications · 81 citations

    3

    h-index

  2. SE
    Scott E. Strome

    University of Maryland, Baltimore, United States

    3 publications · 81 citations

    3

    h-index

  3. EB
    Erin Burch

    University of Maryland, Baltimore, United States

    3 publications · 81 citations

    3

    h-index

  4. EY
    Emmanuel Y. Mérigeon

    University of Maryland, Baltimore, United States

    2 publications · 29 citations

    2

    h-index

  5. MJ
    Matthew J. Memoli

    National Institute of Allergy and Infectious Diseases, United States

    2 publications · 362 citations

    2

    h-index

1–5 of 267

Institutions

82

  1. Amgen (United States)

    Thousand Oaks, United States

    3 h-index

    18 publications

    1.6K citations

  2. Biogen (United States)

    Cambridge, United States

    3 h-index

    19 publications

    528 citations

  3. University of Maryland, Baltimore

    Baltimore, United States

    3 h-index

    25 publications

    823 citations

  4. National Institutes of Health

    Bethesda, United States

    2 h-index

    4 publications

    724 citations

  5. University of California San Diego

    San Diego, United States

    2 h-index

    2 publications

    362 citations

  6. Stanford Blood Center

    Palo Alto, United States

    2 h-index

    2 publications

    362 citations

  7. National Institute of Allergy and Infectious Diseases

    Bethesda, United States

    2 h-index

    4 publications

    724 citations

  8. Gliknik (United States)

    Baltimore, United States

    2 h-index

    7 publications

    105 citations

1–8 of 82

Venues

  1. Molecular Immunology

    5 publications · 176 citations

    5

    h-index

  2. Protein Engineering Design and Selection

    PEDS · 2 publications · 244 citations

    2

    h-index

  3. Frontiers in Immunology

    1 publications · 38 citations

    1

    h-index

  4. American Review of Respiratory Disease

    1 publications · 43 citations

    1

    h-index

  5. Journal of Biological Chemistry

    JBC · 1 publications · 284 citations

    1

    h-index

1–5